Abstract
Injectable drugs are generally administered to newborns with 1 mL syringes. During in-vitro measurements of surface tension with a pulsating bubble surfactometer, we noticed that surfactant was inactivated after repeated aspiration into a 1 mL syringe with a rubber-coated plunger. Inactivation did not take place, however, when we used rubber-free two-part syringes with polyethylene pistons. Results of further studies showed that the silicone fluid used to lubricate the rubber surface of the syringe was inactivating the surfactant. Our findings suggest that contact with rubber surfaces should be avoided in the handling of surfactant material for biophysical assessment or clinical use.
| Original language | English |
|---|---|
| Journal | Lancet |
| Volume | 361 |
| Issue number | 9354 |
| Pages (from-to) | 311-313 |
| Number of pages | 3 |
| ISSN | 0140-6736 |
| DOIs | |
| Publication status | Published - 25.01.2003 |
Funding
We thank Bim Linderholm, Stockholm, and Gabi Walter, Göttingen, for technical assistance. This work was supported in part by the German Research Council (Deutsche Forschungsgemeinschaft: DFG He 2072/2-2) and the Swedish Medical Research Council (project 3351). The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report, or in the decision to submit the paper for publication.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
