Syringes with rubber-coated plungers and inactivation of surfactant

Egbert Herting; Guido Stichtenoth; Bengt Robertson

doi:10.1016/S0140-6736(03)12334-3

Syringes with rubber-coated plungers and inactivation of surfactant

Egbert Herting^*, Guido Stichtenoth, Bengt Robertson

^*Corresponding author for this work

Department of Pediatric and Adolescent Medicine

6 Citations (Scopus)

Abstract

Injectable drugs are generally administered to newborns with 1 mL syringes. During in-vitro measurements of surface tension with a pulsating bubble surfactometer, we noticed that surfactant was inactivated after repeated aspiration into a 1 mL syringe with a rubber-coated plunger. Inactivation did not take place, however, when we used rubber-free two-part syringes with polyethylene pistons. Results of further studies showed that the silicone fluid used to lubricate the rubber surface of the syringe was inactivating the surfactant. Our findings suggest that contact with rubber surfaces should be avoided in the handling of surfactant material for biophysical assessment or clinical use.

Original language	English
Journal	Lancet
Volume	361
Issue number	9354
Pages (from-to)	311-313
Number of pages	3
ISSN	0140-6736
DOIs	https://doi.org/10.1016/S0140-6736(03)12334-3
Publication status	Published - 25.01.2003

Funding

We thank Bim Linderholm, Stockholm, and Gabi Walter, Göttingen, for technical assistance. This work was supported in part by the German Research Council (Deutsche Forschungsgemeinschaft: DFG He 2072/2-2) and the Swedish Medical Research Council (project 3351). The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report, or in the decision to submit the paper for publication.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/S0140-6736(03)12334-3

Cite this

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title = "Syringes with rubber-coated plungers and inactivation of surfactant",

abstract = "Injectable drugs are generally administered to newborns with 1 mL syringes. During in-vitro measurements of surface tension with a pulsating bubble surfactometer, we noticed that surfactant was inactivated after repeated aspiration into a 1 mL syringe with a rubber-coated plunger. Inactivation did not take place, however, when we used rubber-free two-part syringes with polyethylene pistons. Results of further studies showed that the silicone fluid used to lubricate the rubber surface of the syringe was inactivating the surfactant. Our findings suggest that contact with rubber surfaces should be avoided in the handling of surfactant material for biophysical assessment or clinical use.",

author = "Egbert Herting and Guido Stichtenoth and Bengt Robertson",

note = "Funding Information: We thank Bim Linderholm, Stockholm, and Gabi Walter, G{\"o}ttingen, for technical assistance. This work was supported in part by the German Research Council (Deutsche Forschungsgemeinschaft: DFG He 2072/2-2) and the Swedish Medical Research Council (project 3351). The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report, or in the decision to submit the paper for publication. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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doi = "10.1016/S0140-6736(03)12334-3",

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AU - Herting, Egbert

AU - Stichtenoth, Guido

AU - Robertson, Bengt

N1 - Funding Information: We thank Bim Linderholm, Stockholm, and Gabi Walter, Göttingen, for technical assistance. This work was supported in part by the German Research Council (Deutsche Forschungsgemeinschaft: DFG He 2072/2-2) and the Swedish Medical Research Council (project 3351). The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report, or in the decision to submit the paper for publication. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2003/1/25

Y1 - 2003/1/25

N2 - Injectable drugs are generally administered to newborns with 1 mL syringes. During in-vitro measurements of surface tension with a pulsating bubble surfactometer, we noticed that surfactant was inactivated after repeated aspiration into a 1 mL syringe with a rubber-coated plunger. Inactivation did not take place, however, when we used rubber-free two-part syringes with polyethylene pistons. Results of further studies showed that the silicone fluid used to lubricate the rubber surface of the syringe was inactivating the surfactant. Our findings suggest that contact with rubber surfaces should be avoided in the handling of surfactant material for biophysical assessment or clinical use.

AB - Injectable drugs are generally administered to newborns with 1 mL syringes. During in-vitro measurements of surface tension with a pulsating bubble surfactometer, we noticed that surfactant was inactivated after repeated aspiration into a 1 mL syringe with a rubber-coated plunger. Inactivation did not take place, however, when we used rubber-free two-part syringes with polyethylene pistons. Results of further studies showed that the silicone fluid used to lubricate the rubber surface of the syringe was inactivating the surfactant. Our findings suggest that contact with rubber surfaces should be avoided in the handling of surfactant material for biophysical assessment or clinical use.

UR - https://www.scopus.com/pages/publications/0037464768

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DO - 10.1016/S0140-6736(03)12334-3

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JO - Lancet

JF - Lancet

IS - 9354

ER -

Syringes with rubber-coated plungers and inactivation of surfactant

Abstract

Funding

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Research Areas and Centers

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