Synthesis and biological applications of 2,, 3l-dideoxynucleoside-5'-o-(<x-77//0)TRIPHOSPHATES

M. Auer; R. S. Goody; G. Sczakiel; S. WeiB

doi:10.1080/07328318908054228

Synthesis and biological applications of 2,, 3^l-dideoxynucleoside-5'-o-(<x-77//0)TRIPHOSPHATES

M. Auer, R. S. Goody, G. Sczakiel, S. WeiB

Abstract

Fast and efficient syntheses of 2-3, -dideoxynucleoside-5, -0-(a-f/t2o)tiiphosphates (a-S-ddNTP’s) starting from 2'-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3'-deoxythymidine is presented and compared to other known T-dideoxynucleoside structures.

Original language	English
Journal	Nucleosides and Nucleotides
Volume	8
Issue number	5-6
Pages (from-to)	849-853
Number of pages	5
ISSN	0732-8311
DOIs	https://doi.org/10.1080/07328318908054228
Publication status	Published - 01.01.1989

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10.1080/07328318908054228

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title = "Synthesis and biological applications of 2,, 3l-dideoxynucleoside-5'-o-(",

abstract = "Fast and efficient syntheses of 2-3, -dideoxynucleoside-5, -0-(a-f/t2o)tiiphosphates (a-S-ddNTP{\textquoteright}s) starting from 2'-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3'-deoxythymidine is presented and compared to other known T-dideoxynucleoside structures.",

author = "M. Auer and Goody, \{R. S.\} and G. Sczakiel and S. WeiB",

year = "1989",

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AU - Auer, M.

AU - Goody, R. S.

AU - Sczakiel, G.

AU - WeiB, S.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Fast and efficient syntheses of 2-3, -dideoxynucleoside-5, -0-(a-f/t2o)tiiphosphates (a-S-ddNTP’s) starting from 2'-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3'-deoxythymidine is presented and compared to other known T-dideoxynucleoside structures.

AB - Fast and efficient syntheses of 2-3, -dideoxynucleoside-5, -0-(a-f/t2o)tiiphosphates (a-S-ddNTP’s) starting from 2'-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3'-deoxythymidine is presented and compared to other known T-dideoxynucleoside structures.

UR - https://www.scopus.com/pages/publications/0024312673

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JO - Nucleosides and Nucleotides

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IS - 5-6

ER -

Synthesis and biological applications of 2,, 3^l-dideoxynucleoside-5'-o-(<x-77//0)TRIPHOSPHATES

Abstract

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