Synthesis and biological applications of 2,, 3l-dideoxynucleoside-5'-o-(<x-77//0)TRIPHOSPHATES

M. Auer, R. S. Goody, G. Sczakiel, S. WeiB

3 Citations (Scopus)


Fast and efficient syntheses of 2-3, -dideoxynucleoside-5, -0-(a-f/t2o)tiiphosphates (a-S-ddNTP’s) starting from 2'-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3'-deoxythymidine is presented and compared to other known T-dideoxynucleoside structures.

Original languageEnglish
JournalNucleosides and Nucleotides
Issue number5-6
Pages (from-to)849-853
Number of pages5
Publication statusPublished - 01.01.1989


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