Switchable lateral resolution real-time MHz-OCT rectoscopy for enhanced colorectal disease diagnosis

Sazgar Burhan, Berenice Schulte, Madita Göb, Awanish Pratap Singh, Bayan Mustafa, Simon Lotz, Wolfgang Draxinger, Philipp Lamminger, Yasmeine Saker, Tim Eixmann, Martin Ahrens, Marvin Heimke, Tillmann Heinze, Thilo Wedel, Maik Rahlves, Mark Ellrichmann, Robert Huber

Abstract

Endoscopic optical coherence tomography (OCT) offers in vivo live visualization of transmural structures with histological resolution, making it a valuable tool in medical imaging. In gastroenterology, OCT endoscopy is particularly advantageous for assessing rectal wall layers, providing superior axial and lateral resolution compared to conventional rectal endoscopic ultrasound. However, the large diameter and uneven colon surface present challenges for comprehensive imaging. Extending the OCT imaging range addresses this issue by enabling a thorough examination of the entire colon, facilitating the detection of surface polyps, tumors, and their infiltration depth. Once these regions of interest are identified, high-resolution imaging becomes essential for detailed evaluation. To meet these demands, this study integrates two different imaging modes, an extended-range mode, and a high-detail mode, within a rigid rectoscope. The extended-range mode enables visualization of deeper structures, while the high-detail mode enhances image quality for precise, contact-based assessments. The system allows seamless, real-time transitions between the modes using a 3.2MHz-OCT system and a fiber‑optic MEMS switch.
Original languageEnglish
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIX
EditorsRainer A. Leitgeb, Yoshiaki Yasuno
Number of pages1
Volume13305
PublisherSPIE
Publication date03.2025
Pages1330512
DOIs
Publication statusPublished - 03.2025

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