Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

DZIF-ATHOS Study Group

doi:10.1016/j.ijantimicag.2016.10.013

Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

DZIF-ATHOS Study Group

Abstract

As part of the multicentre Antibiotic Therapy Optimisation Study (ATHOS), minimum inhibitory concentrations (MICs) were determined for cephalosporins alone and in combination with the β-lactamase inhibitors tazobactam, clavulanic acid and avibactam against third-generation cephalosporin-resistant Escherichia coli, Klebsiella spp. and Enterobacter spp. isolates collected in German hospitals. MIC_50/90 values were 0.25–4 mg/L for cefepime/tazobactam, 0.25–2 mg/L for ceftazidime/avibactam, 0.125–0.5 mg/L for ceftaroline/avibactam, 0.5–4 mg/L for cefpodoxime/clavulanic acid and 0.25–1 mg/L for aztreonam/avibactam, depending on the underlying resistance mechanism and organism. Based on in vitro testing, β-lactam antibiotics play an important role in the treatment of infections due to β-lactamase-producing organisms.

Original language	English
Journal	International Journal of Antimicrobial Agents
Volume	49
Issue number	2
Pages (from-to)	239-242
Number of pages	4
ISSN	0924-8579
DOIs	https://doi.org/10.1016/j.ijantimicag.2016.10.013
Publication status	Published - 01.02.2017

Funding

Funding: This study was supported by the German Center for Infection Research (DZIF).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1016/j.ijantimicag.2016.10.013

Cite this

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title = "Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission",

abstract = "As part of the multicentre Antibiotic Therapy Optimisation Study (ATHOS), minimum inhibitory concentrations (MICs) were determined for cephalosporins alone and in combination with the β-lactamase inhibitors tazobactam, clavulanic acid and avibactam against third-generation cephalosporin-resistant Escherichia coli, Klebsiella spp. and Enterobacter spp. isolates collected in German hospitals. MIC50/90 values were 0.25–4 mg/L for cefepime/tazobactam, 0.25–2 mg/L for ceftazidime/avibactam, 0.125–0.5 mg/L for ceftaroline/avibactam, 0.5–4 mg/L for cefpodoxime/clavulanic acid and 0.25–1 mg/L for aztreonam/avibactam, depending on the underlying resistance mechanism and organism. Based on in vitro testing, β-lactam antibiotics play an important role in the treatment of infections due to β-lactamase-producing organisms.",

author = "Alexander Mischnik and Philipp Baumert and Axel Hamprecht and Anna Rohde and Silke Peter and Susanne Feihl and Johannes Knobloch and Hanna G{\"o}lz and Axel Kola and Birgit Obermann and Christiane Querbach and Matthias Willmann and Friedemann Gebhardt and Evelina Tacconelli and Petra Gastmeier and Harald Seifert and \{DZIF-ATHOS Study Group\} and Kern, \{Winfried V.\}",

year = "2017",

month = feb,

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doi = "10.1016/j.ijantimicag.2016.10.013",

language = "English",

volume = "49",

pages = "239--242",

journal = "International Journal of Antimicrobial Agents",

issn = "0924-8579",

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T1 - Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

AU - Mischnik, Alexander

AU - Baumert, Philipp

AU - Hamprecht, Axel

AU - Rohde, Anna

AU - Peter, Silke

AU - Feihl, Susanne

AU - Knobloch, Johannes

AU - Gölz, Hanna

AU - Kola, Axel

AU - Obermann, Birgit

AU - Querbach, Christiane

AU - Willmann, Matthias

AU - Gebhardt, Friedemann

AU - Tacconelli, Evelina

AU - Gastmeier, Petra

AU - Seifert, Harald

AU - DZIF-ATHOS Study Group

AU - Kern, Winfried V.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - As part of the multicentre Antibiotic Therapy Optimisation Study (ATHOS), minimum inhibitory concentrations (MICs) were determined for cephalosporins alone and in combination with the β-lactamase inhibitors tazobactam, clavulanic acid and avibactam against third-generation cephalosporin-resistant Escherichia coli, Klebsiella spp. and Enterobacter spp. isolates collected in German hospitals. MIC50/90 values were 0.25–4 mg/L for cefepime/tazobactam, 0.25–2 mg/L for ceftazidime/avibactam, 0.125–0.5 mg/L for ceftaroline/avibactam, 0.5–4 mg/L for cefpodoxime/clavulanic acid and 0.25–1 mg/L for aztreonam/avibactam, depending on the underlying resistance mechanism and organism. Based on in vitro testing, β-lactam antibiotics play an important role in the treatment of infections due to β-lactamase-producing organisms.

AB - As part of the multicentre Antibiotic Therapy Optimisation Study (ATHOS), minimum inhibitory concentrations (MICs) were determined for cephalosporins alone and in combination with the β-lactamase inhibitors tazobactam, clavulanic acid and avibactam against third-generation cephalosporin-resistant Escherichia coli, Klebsiella spp. and Enterobacter spp. isolates collected in German hospitals. MIC50/90 values were 0.25–4 mg/L for cefepime/tazobactam, 0.25–2 mg/L for ceftazidime/avibactam, 0.125–0.5 mg/L for ceftaroline/avibactam, 0.5–4 mg/L for cefpodoxime/clavulanic acid and 0.25–1 mg/L for aztreonam/avibactam, depending on the underlying resistance mechanism and organism. Based on in vitro testing, β-lactam antibiotics play an important role in the treatment of infections due to β-lactamase-producing organisms.

UR - https://www.scopus.com/pages/publications/85008214271

U2 - 10.1016/j.ijantimicag.2016.10.013

DO - 10.1016/j.ijantimicag.2016.10.013

M3 - Journal articles

C2 - 27939093

AN - SCOPUS:85008214271

SN - 0924-8579

VL - 49

SP - 239

EP - 242

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 2

ER -

Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

Abstract

Funding

UN SDGs

Research Areas and Centers

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