Survival of endometrial cancer patients in Germany in the early 21st century: A period analysis by age, histology, and stage

Tianhui Chen*, Lina Jansen, Adam Gondos, Meike Ressing, Bernd Holleczek, Alexander Katalinic, Hermann Brenner

*Corresponding author for this work
9 Citations (Scopus)

Abstract

Background: Population-based studies on endometrial cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for endometrial cancer patients in Germany.Methods: We used a pooled German national dataset including data from 11 cancer registries covering a population of 33 million people. 30,906 patients diagnosed with endometrial cancer in 1997-2006 were included. Period analysis was performed to calculate 5-year relative survival (RS) in 2002-2006. Trends in survival between 2002 and 2006 were examined using model-based period analysis. Age-adjustment was performed using five age groups (15-44, 45-54, 55-64, 65-74, and 75+ years).Results: Overall, age-adjusted 5-year relative survival in 2002-2006 was 81%. A moderate age gradient was observed, with 5-year RS decreasing from 90% in the age group 15-49 years to 75% in the age group 70+ years. Furthermore prognosis varied strongly by histologic subtypes and stage, with age-adjusted 5-year RS ranging from 43% (for sarcoma) to 94% (for squamous metaplasia), and reaching 91% for localized, 51% for regional, and 20% for distant stage. Except for age group 65-74 years, no significant improvement in survival was seen during the recent 5-year period under investigation.Conclusion: In this comprehensive population-based survival analysis of patients with endometrial cancer from Germany, prognosis of endometrial cancer moderately varied by age, and strongly varied by histology and stage. While prognosis is rather good overall, further improvement in 5-year relative survival of endometrial cancer patients has been stagnating in the early 21 st century.

Original languageEnglish
Article number128
JournalBMC Cancer
Volume12
ISSN0008-5472
DOIs
Publication statusPublished - 30.03.2012

Fingerprint

Dive into the research topics of 'Survival of endometrial cancer patients in Germany in the early 21st century: A period analysis by age, histology, and stage'. Together they form a unique fingerprint.

Cite this