Survival of diabetes patients with major amputation is comparable to malignant disease

Martin Hoffmann*, Peter Kujath, Annette Flemming, Moritz Proß, Nehara Begum, Markus Zimmermann, Tobias Keck, Markus Kleemann, Erik Schloericke

*Corresponding author for this work
26 Citations (Scopus)


Introduction: Almost all studies on diabetic foot syndrome focused on prevention of amputation and did not investigate long-term prognosis and survival of patients as a primary outcome parameter. Methods: We did a retrospective cohort study including 314 patients who had diabetic foot syndrome and underwent amputation between December 1995 and January 2001. Results: A total of 48% of patients received minor amputation (group I), 15% only major amputation (group II) and 36% initially underwent a minor amputation that was followed by a major amputation (group III). Statistically significant differences were observed in comparison of the median survival of group I to group II (51 vs 40 months; p = 0.016) and of group II to group III (40 vs 55 months; p = 0.003). Discussion: The prognosis of patients with major amputation due to diabetic foot syndrome is comparable to patients with malignant diseases. Vascular interventions did not improve the individual prognosis of patients.

Original languageEnglish
JournalDiabetes and Vascular Disease Research
Issue number4
Pages (from-to)265-271
Number of pages7
Publication statusPublished - 11.07.2015

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


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