Survival of cervical cancer patients in Germany in the early 21st century: A period analysis by age, histology, and stage

Tianhui Chen, Lina Jansen, Adam Gondos, Katharina Emrich, Bernd Holleczek, Sabine Luttmann, Annika Waldmann, Hermann Brenner*

*Corresponding author for this work
18 Citations (Scopus)

Abstract

Purpose. Population-based studies on cervical cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for cervical cancer patients in Germany. Methods. We used a pooled German national dataset including data from 11 cancer registries covering a population of 33 million people. Included were 15 685 patients diagnosed with cervical cancer from 1997 to 2006. Period analysis was performed to calculate the five-year relative survival (RS) 20022006. Trends in survival between 2002 and 2006 were examined using model-based period analysis. Age-adjustment was done using five age groups (1544, 4554, 5564, 6574, and 75 years). Results. Overall, age-adjusted five-year relative survival in 20022006 was 64.7%. A strong age gradient was observed, with five-year RS decreasing from 81.7% in age group 1549 years to 46.3% in age group 70 years. Prognosis furthermore strongly varied by stage, with age-adjusted five-year RS reaching 84.6% for localized, 48.2% for regional, and 17.9% for distant stage. From 2002 to 2006, a significant improvement (4.7 percent units) in overall age-adjusted five-year RS was seen. The improvement was most pronounced for age groups 5564 years (from 54.2 to 65.6%) and 6574 years (from 50.0 to 58.1%). Conclusion. In this first comprehensive population-based study from Germany, prognosis of cervical cancer strongly varied by age and stage. Prognosis continued to improve, in particular in age range 5574 years, in the five-year period assessed.

Original languageEnglish
JournalActa Oncologica
Volume51
Issue number7
Pages (from-to)915-921
Number of pages7
ISSN0284-186X
DOIs
Publication statusPublished - 09.2012

Research Areas and Centers

  • Research Area: Center for Population Medicine and Public Health (ZBV)

DFG Research Classification Scheme

  • 205-02 Public Health, Health Services Research and Social Medicine
  • 205-14 Haematology, Oncology
  • 205-21 Gynaecology and Obstetrics

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