TY - JOUR
T1 - Survival of cervical cancer patients in Germany in the early 21st century: A period analysis by age, histology, and stage
AU - Chen, Tianhui
AU - Jansen, Lina
AU - Gondos, Adam
AU - Emrich, Katharina
AU - Holleczek, Bernd
AU - Luttmann, Sabine
AU - Waldmann, Annika
AU - Brenner, Hermann
N1 - Funding Information:
Members of the GEKID Cancer Survival Working Group: Karla Geiss, Martin Meyer (Cancer Registry of Bavaria), Andrea Eberle, Sabine Luttmann (Cancer Registry of Bremen), Roland Stabenow (Cancer Registry of Berlin and the New Federal States), Stefan Hentschel, Alice Nennecke (Hamburg Cancer Registry), Joachim Kieschke, Eunice Sirri (Cancer Registry of Lower Saxony), Bernd Hol-leczek (Saarland Cancer Registry), Katharina Emrich (Cancer Registry of Rhineland-Palatinate), Hiltraud Kaj ü ter, Volkmar Mattauch (Cancer Registry of North Rhine-Westphalia), Alexander Katalinic (Cancer Registry of Schleswig-Holstein), Klaus Kraywin-kel (Robert Koch Institute, Berlin), Hermann Brenner, Lina Jansen, Adam Gondos (DKFZ). This study was funded by German Cancer Aid (Deutsche Krebshilfe), grant no. 108257. The sponsor had no role in the study design, collection, analysis, or interpretation of data.
PY - 2012/9
Y1 - 2012/9
N2 - Purpose. Population-based studies on cervical cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for cervical cancer patients in Germany. Methods. We used a pooled German national dataset including data from 11 cancer registries covering a population of 33 million people. Included were 15 685 patients diagnosed with cervical cancer from 1997 to 2006. Period analysis was performed to calculate the five-year relative survival (RS) 20022006. Trends in survival between 2002 and 2006 were examined using model-based period analysis. Age-adjustment was done using five age groups (1544, 4554, 5564, 6574, and 75 years). Results. Overall, age-adjusted five-year relative survival in 20022006 was 64.7%. A strong age gradient was observed, with five-year RS decreasing from 81.7% in age group 1549 years to 46.3% in age group 70 years. Prognosis furthermore strongly varied by stage, with age-adjusted five-year RS reaching 84.6% for localized, 48.2% for regional, and 17.9% for distant stage. From 2002 to 2006, a significant improvement (4.7 percent units) in overall age-adjusted five-year RS was seen. The improvement was most pronounced for age groups 5564 years (from 54.2 to 65.6%) and 6574 years (from 50.0 to 58.1%). Conclusion. In this first comprehensive population-based study from Germany, prognosis of cervical cancer strongly varied by age and stage. Prognosis continued to improve, in particular in age range 5574 years, in the five-year period assessed.
AB - Purpose. Population-based studies on cervical cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for cervical cancer patients in Germany. Methods. We used a pooled German national dataset including data from 11 cancer registries covering a population of 33 million people. Included were 15 685 patients diagnosed with cervical cancer from 1997 to 2006. Period analysis was performed to calculate the five-year relative survival (RS) 20022006. Trends in survival between 2002 and 2006 were examined using model-based period analysis. Age-adjustment was done using five age groups (1544, 4554, 5564, 6574, and 75 years). Results. Overall, age-adjusted five-year relative survival in 20022006 was 64.7%. A strong age gradient was observed, with five-year RS decreasing from 81.7% in age group 1549 years to 46.3% in age group 70 years. Prognosis furthermore strongly varied by stage, with age-adjusted five-year RS reaching 84.6% for localized, 48.2% for regional, and 17.9% for distant stage. From 2002 to 2006, a significant improvement (4.7 percent units) in overall age-adjusted five-year RS was seen. The improvement was most pronounced for age groups 5564 years (from 54.2 to 65.6%) and 6574 years (from 50.0 to 58.1%). Conclusion. In this first comprehensive population-based study from Germany, prognosis of cervical cancer strongly varied by age and stage. Prognosis continued to improve, in particular in age range 5574 years, in the five-year period assessed.
UR - http://www.scopus.com/inward/record.url?scp=84866409997&partnerID=8YFLogxK
U2 - 10.3109/0284186X.2012.708105
DO - 10.3109/0284186X.2012.708105
M3 - Journal articles
C2 - 22928692
AN - SCOPUS:84866409997
VL - 51
SP - 915
EP - 921
JO - Acta oncologica (Stockholm, Sweden)
JF - Acta oncologica (Stockholm, Sweden)
SN - 0284-186X
IS - 7
ER -