TY - JOUR
T1 - Survival in patients with metastatic spinal cord compression from prostate cancer is associated with the number of extra-spinal organs involved
AU - Weber, Axel
AU - Bartscht, Tobias
AU - Karstens, Johann H.
AU - Schild, Steven E.
AU - Rades, Dirk
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Background/Aim: To investigate the predictive value of the number of extra-spinal organs involved by metastases for survival in metastatic spinal cord compression (MSCC) from prostate cancer. Patients and Methods: In 95 patients irradiated with 10x3 Gy for MSCC from prostate cancer, seven factors were investigated: Age, performance score, number of involved vertebrae, interval from prostate cancer diagnosis to MSCC, pre-radiotherapy ambulatory status, time to motor deficits development, number of involved extra-spinal organs. Results: Six-month survival rates for 0, 1 and ≥2 involved extra-spinal organs, were 81, 53 and 33%, respectively (p<0.001). On multivariate analysis, the number of involved extra-spinal organs maintained significance (risk ratio 1.88, p=0.023). Better performance score (p<0.001), longer interval from prostate cancer diagnosis to radiotherapy of MSCC (p<0.001), and being ambulatory prior to radiotherapy (p=0.001) were also positively associated with survival. Conclusion: The number of extra-spinal organs involved by metastases predicts survival in patients with MSCC from prostate cancer.
AB - Background/Aim: To investigate the predictive value of the number of extra-spinal organs involved by metastases for survival in metastatic spinal cord compression (MSCC) from prostate cancer. Patients and Methods: In 95 patients irradiated with 10x3 Gy for MSCC from prostate cancer, seven factors were investigated: Age, performance score, number of involved vertebrae, interval from prostate cancer diagnosis to MSCC, pre-radiotherapy ambulatory status, time to motor deficits development, number of involved extra-spinal organs. Results: Six-month survival rates for 0, 1 and ≥2 involved extra-spinal organs, were 81, 53 and 33%, respectively (p<0.001). On multivariate analysis, the number of involved extra-spinal organs maintained significance (risk ratio 1.88, p=0.023). Better performance score (p<0.001), longer interval from prostate cancer diagnosis to radiotherapy of MSCC (p<0.001), and being ambulatory prior to radiotherapy (p=0.001) were also positively associated with survival. Conclusion: The number of extra-spinal organs involved by metastases predicts survival in patients with MSCC from prostate cancer.
UR - http://www.scopus.com/inward/record.url?scp=84891360815&partnerID=8YFLogxK
M3 - Journal articles
C2 - 24123022
AN - SCOPUS:84891360815
SN - 0250-7005
VL - 33
SP - 4505
EP - 4507
JO - Anticancer Research
JF - Anticancer Research
IS - 10
ER -
