Survival after out-of-hospital cardiac arrest in Europe - Results of the EuReCa TWO study

Jan Thorsten Gräsner; Jan Wnent; Johan Herlitz; Gavin D. Perkins; Rolf Lefering; Ingvild Tjelmeland; Rudolph W. Koster; Siobhán Masterson; Fernando Rossell-Ortiz; Holger Maurer; Bernd W. Böttiger; Maximilian Moertl; Pierre Mols; Hajriz Alihodžić; Irzal Hadžibegović; Marios Ioannides; Anatolij Truhlář; Mads Wissenberg; Ari Salo; Josephine Escutnaire; Nikolaos Nikolaou; Eniko Nagy; Bergthor Steinn Jonsson; Peter Wright; Federico Semeraro; Carlo Clarens; Steffie Beesems; Grzegorz Cebula; Vitor H. Correia; Diana Cimpoesu; Violetta Raffay; Stefan Trenkler; Andrej Markota; Anneli Strömsöe; Roman Burkart; Scott Booth; Leo Bossaert

doi:10.1016/j.resuscitation.2019.12.042

Survival after out-of-hospital cardiac arrest in Europe - Results of the EuReCa TWO study

Jan Thorsten Gräsner^*, Jan Wnent, Johan Herlitz, Gavin D. Perkins, Rolf Lefering, Ingvild Tjelmeland, Rudolph W. Koster, Siobhán Masterson, Fernando Rossell-Ortiz, Holger Maurer, Bernd W. Böttiger, Maximilian Moertl, Pierre Mols, Hajriz Alihodžić, Irzal Hadžibegović, Marios Ioannides, Anatolij Truhlář, Mads Wissenberg, Ari Salo, Josephine EscutnaireNikolaos Nikolaou, Eniko Nagy, Bergthor Steinn Jonsson, Peter Wright, Federico Semeraro, Carlo Clarens, Steffie Beesems, Grzegorz Cebula, Vitor H. Correia, Diana Cimpoesu, Violetta Raffay, Stefan Trenkler, Andrej Markota, Anneli Strömsöe, Roman Burkart, Scott Booth, Leo Bossaert

^*Corresponding author for this work

Department of Anesthesiology and Intensive Care Medicine

776 Citations (Scopus)

Abstract

Background: The epidemiology and outcome after out-of-hospital cardiac arrest (OHCA) varies across Europe. Following on from EuReCa ONE, the aim of this study was to further explore the incidence of and outcomes from OHCA in Europe and to improve understanding of the role of the bystander. Methods: This prospective, multicentre study involved the collection of registry-based data over a three-month period (1st October 2017 to 31st December 2017). The core study dataset complied with the Utstein-style. Primary outcomes were return of spontaneous circulation (ROSC) and survival to hospital admission. Secondary outcome was survival to hospital discharge. Results: All 28 countries provided data, covering a total population of 178,879,118. A total of 37,054 OHCA were confirmed, with CPR being started in 25,171 cases. The bystander cardiopulmonary resuscitation (CPR) rate ranged from 13% to 82% between countries (average: 58%). In one third of cases (33%) ROSC was achieved and 8% of patients were discharged from hospital alive. Survival to hospital discharge was higher in patients when a bystander performed CPR with ventilations, compared to compression-only CPR (14% vs. 8% respectively). Conclusion: In addition to increasing our understanding of the role of bystander CPR within Europe, EuReCa TWO has confirmed large variation in OHCA incidence, characteristics and outcome, and highlighted the extent to which OHCA is a public health burden across Europe. Unexplained variation remains and the EuReCa network has a continuing role to play in improving the quality management of resuscitation.

Original language	English
Journal	Resuscitation
Volume	148
Pages (from-to)	218-226
Number of pages	9
ISSN	0300-9572
DOIs	https://doi.org/10.1016/j.resuscitation.2019.12.042
Publication status	Published - 01.03.2020

Funding

The EuReCa TWO study was supported by the ERC Research NET. The authors furthermore want to thank the EuReCa TWO Steering Committee and Study Management Team, namely Jan-Thorsten Gräsner, Leo Bossaert, Rudolph W. Koster, Johan Herlitz, Bernd W. Böttiger, Ingvild Tjelmeland, Siobhán Masterson, Jan Wnent, Fernando Rossel-Ortiz, Holger Maurer, and Gavin D. Perkins as well as the statistician Rolf Lefering for the huge effort made in running the study.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.resuscitation.2019.12.042

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Gräsner, J. T., Wnent, J., Herlitz, J., Perkins, G. D., Lefering, R., Tjelmeland, I., Koster, R. W., Masterson, S., Rossell-Ortiz, F., Maurer, H., Böttiger, B. W., Moertl, M., Mols, P., Alihodžić, H., Hadžibegović, I., Ioannides, M., Truhlář, A., Wissenberg, M., Salo, A., ... Bossaert, L. (2020). Survival after out-of-hospital cardiac arrest in Europe - Results of the EuReCa TWO study. Resuscitation, 148, 218-226. https://doi.org/10.1016/j.resuscitation.2019.12.042

@article{22c95dc5b152492d8fb46bb0f19cdb17,

title = "Survival after out-of-hospital cardiac arrest in Europe - Results of the EuReCa TWO study",

abstract = "Background: The epidemiology and outcome after out-of-hospital cardiac arrest (OHCA) varies across Europe. Following on from EuReCa ONE, the aim of this study was to further explore the incidence of and outcomes from OHCA in Europe and to improve understanding of the role of the bystander. Methods: This prospective, multicentre study involved the collection of registry-based data over a three-month period (1st October 2017 to 31st December 2017). The core study dataset complied with the Utstein-style. Primary outcomes were return of spontaneous circulation (ROSC) and survival to hospital admission. Secondary outcome was survival to hospital discharge. Results: All 28 countries provided data, covering a total population of 178,879,118. A total of 37,054 OHCA were confirmed, with CPR being started in 25,171 cases. The bystander cardiopulmonary resuscitation (CPR) rate ranged from 13\% to 82\% between countries (average: 58\%). In one third of cases (33\%) ROSC was achieved and 8\% of patients were discharged from hospital alive. Survival to hospital discharge was higher in patients when a bystander performed CPR with ventilations, compared to compression-only CPR (14\% vs. 8\% respectively). Conclusion: In addition to increasing our understanding of the role of bystander CPR within Europe, EuReCa TWO has confirmed large variation in OHCA incidence, characteristics and outcome, and highlighted the extent to which OHCA is a public health burden across Europe. Unexplained variation remains and the EuReCa network has a continuing role to play in improving the quality management of resuscitation.",

author = "Gr{\"a}sner, \{Jan Thorsten\} and Jan Wnent and Johan Herlitz and Perkins, \{Gavin D.\} and Rolf Lefering and Ingvild Tjelmeland and Koster, \{Rudolph W.\} and Siobh{\'a}n Masterson and Fernando Rossell-Ortiz and Holger Maurer and B{\"o}ttiger, \{Bernd W.\} and Maximilian Moertl and Pierre Mols and Hajriz Alihod{\v z}i{\'c} and Irzal Had{\v z}ibegovi{\'c} and Marios Ioannides and Anatolij Truhl{\'a}{\v r} and Mads Wissenberg and Ari Salo and Josephine Escutnaire and Nikolaos Nikolaou and Eniko Nagy and Jonsson, \{Bergthor Steinn\} and Peter Wright and Federico Semeraro and Carlo Clarens and Steffie Beesems and Grzegorz Cebula and Correia, \{Vitor H.\} and Diana Cimpoesu and Violetta Raffay and Stefan Trenkler and Andrej Markota and Anneli Str{\"o}ms{\"o}e and Roman Burkart and Scott Booth and Leo Bossaert",

note = "Funding Information: The EuReCa TWO study was supported by the ERC Research NET. The authors furthermore want to thank the EuReCa TWO Steering Committee and Study Management Team, namely Jan-Thorsten Gr{\"a}sner, Leo Bossaert, Rudolph W. Koster, Johan Herlitz, Bernd W. B{\"o}ttiger, Ingvild Tjelmeland, Siobh{\'a}n Masterson, Jan Wnent, Fernando Rossel-Ortiz, Holger Maurer, and Gavin D. Perkins as well as the statistician Rolf Lefering for the huge effort made in running the study. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = mar,

day = "1",

doi = "10.1016/j.resuscitation.2019.12.042",

language = "English",

volume = "148",

pages = "218--226",

journal = "Resuscitation",

issn = "0300-9572",

publisher = "Elsevier Ireland Ltd",

}

Gräsner, JT, Wnent, J, Herlitz, J, Perkins, GD, Lefering, R, Tjelmeland, I, Koster, RW, Masterson, S, Rossell-Ortiz, F, Maurer, H, Böttiger, BW, Moertl, M, Mols, P, Alihodžić, H, Hadžibegović, I, Ioannides, M, Truhlář, A, Wissenberg, M, Salo, A, Escutnaire, J, Nikolaou, N, Nagy, E, Jonsson, BS, Wright, P, Semeraro, F, Clarens, C, Beesems, S, Cebula, G, Correia, VH, Cimpoesu, D, Raffay, V, Trenkler, S, Markota, A, Strömsöe, A, Burkart, R, Booth, S & Bossaert, L 2020, 'Survival after out-of-hospital cardiac arrest in Europe - Results of the EuReCa TWO study', Resuscitation, vol. 148, pp. 218-226. https://doi.org/10.1016/j.resuscitation.2019.12.042

TY - JOUR

T1 - Survival after out-of-hospital cardiac arrest in Europe - Results of the EuReCa TWO study

AU - Gräsner, Jan Thorsten

AU - Wnent, Jan

AU - Herlitz, Johan

AU - Perkins, Gavin D.

AU - Lefering, Rolf

AU - Tjelmeland, Ingvild

AU - Koster, Rudolph W.

AU - Masterson, Siobhán

AU - Rossell-Ortiz, Fernando

AU - Maurer, Holger

AU - Böttiger, Bernd W.

AU - Moertl, Maximilian

AU - Mols, Pierre

AU - Alihodžić, Hajriz

AU - Hadžibegović, Irzal

AU - Ioannides, Marios

AU - Truhlář, Anatolij

AU - Wissenberg, Mads

AU - Salo, Ari

AU - Escutnaire, Josephine

AU - Nikolaou, Nikolaos

AU - Nagy, Eniko

AU - Jonsson, Bergthor Steinn

AU - Wright, Peter

AU - Semeraro, Federico

AU - Clarens, Carlo

AU - Beesems, Steffie

AU - Cebula, Grzegorz

AU - Correia, Vitor H.

AU - Cimpoesu, Diana

AU - Raffay, Violetta

AU - Trenkler, Stefan

AU - Markota, Andrej

AU - Strömsöe, Anneli

AU - Burkart, Roman

AU - Booth, Scott

AU - Bossaert, Leo

N1 - Funding Information: The EuReCa TWO study was supported by the ERC Research NET. The authors furthermore want to thank the EuReCa TWO Steering Committee and Study Management Team, namely Jan-Thorsten Gräsner, Leo Bossaert, Rudolph W. Koster, Johan Herlitz, Bernd W. Böttiger, Ingvild Tjelmeland, Siobhán Masterson, Jan Wnent, Fernando Rossel-Ortiz, Holger Maurer, and Gavin D. Perkins as well as the statistician Rolf Lefering for the huge effort made in running the study. Publisher Copyright: © 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Background: The epidemiology and outcome after out-of-hospital cardiac arrest (OHCA) varies across Europe. Following on from EuReCa ONE, the aim of this study was to further explore the incidence of and outcomes from OHCA in Europe and to improve understanding of the role of the bystander. Methods: This prospective, multicentre study involved the collection of registry-based data over a three-month period (1st October 2017 to 31st December 2017). The core study dataset complied with the Utstein-style. Primary outcomes were return of spontaneous circulation (ROSC) and survival to hospital admission. Secondary outcome was survival to hospital discharge. Results: All 28 countries provided data, covering a total population of 178,879,118. A total of 37,054 OHCA were confirmed, with CPR being started in 25,171 cases. The bystander cardiopulmonary resuscitation (CPR) rate ranged from 13% to 82% between countries (average: 58%). In one third of cases (33%) ROSC was achieved and 8% of patients were discharged from hospital alive. Survival to hospital discharge was higher in patients when a bystander performed CPR with ventilations, compared to compression-only CPR (14% vs. 8% respectively). Conclusion: In addition to increasing our understanding of the role of bystander CPR within Europe, EuReCa TWO has confirmed large variation in OHCA incidence, characteristics and outcome, and highlighted the extent to which OHCA is a public health burden across Europe. Unexplained variation remains and the EuReCa network has a continuing role to play in improving the quality management of resuscitation.

AB - Background: The epidemiology and outcome after out-of-hospital cardiac arrest (OHCA) varies across Europe. Following on from EuReCa ONE, the aim of this study was to further explore the incidence of and outcomes from OHCA in Europe and to improve understanding of the role of the bystander. Methods: This prospective, multicentre study involved the collection of registry-based data over a three-month period (1st October 2017 to 31st December 2017). The core study dataset complied with the Utstein-style. Primary outcomes were return of spontaneous circulation (ROSC) and survival to hospital admission. Secondary outcome was survival to hospital discharge. Results: All 28 countries provided data, covering a total population of 178,879,118. A total of 37,054 OHCA were confirmed, with CPR being started in 25,171 cases. The bystander cardiopulmonary resuscitation (CPR) rate ranged from 13% to 82% between countries (average: 58%). In one third of cases (33%) ROSC was achieved and 8% of patients were discharged from hospital alive. Survival to hospital discharge was higher in patients when a bystander performed CPR with ventilations, compared to compression-only CPR (14% vs. 8% respectively). Conclusion: In addition to increasing our understanding of the role of bystander CPR within Europe, EuReCa TWO has confirmed large variation in OHCA incidence, characteristics and outcome, and highlighted the extent to which OHCA is a public health burden across Europe. Unexplained variation remains and the EuReCa network has a continuing role to play in improving the quality management of resuscitation.

UR - https://www.scopus.com/pages/publications/85079158573

U2 - 10.1016/j.resuscitation.2019.12.042

DO - 10.1016/j.resuscitation.2019.12.042

M3 - Journal articles

C2 - 32027980

AN - SCOPUS:85079158573

SN - 0300-9572

VL - 148

SP - 218

EP - 226

JO - Resuscitation

JF - Resuscitation

ER -

Survival after out-of-hospital cardiac arrest in Europe - Results of the EuReCa TWO study

Abstract

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UN SDGs

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