[18F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism

Pramod K. Pal; Joanne Leung; Katya Hedrich; Ali Samii; Abraham Lieberman; Paul A. Nausieda; Donald B. Calne; Xandra O. Breakefield; Christine Klein; A. Jon Stoessl

doi:10.1002/mds.10133

[¹⁸F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism

Pramod K. Pal, Joanne Leung, Katya Hedrich, Ali Samii, Abraham Lieberman, Paul A. Nausieda, Donald B. Calne, Xandra O. Breakefield, Christine Klein, A. Jon Stoessl^*

^*Corresponding author for this work

Institute of Neurogenetics

18 Citations (Scopus)

Abstract

There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of ¹⁸F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.

Original language	English
Journal	Movement Disorders
Volume	17
Issue number	4
Pages (from-to)	789-794
Number of pages	6
ISSN	0885-3185
DOIs	https://doi.org/10.1002/mds.10133
Publication status	Published - 01.07.2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1002/mds.10133

Cite this

@article{efba673e72c34f409b49f75fdcedf60d,

title = "[18F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism",

abstract = "There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of 18F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.",

author = "Pal, \{Pramod K.\} and Joanne Leung and Katya Hedrich and Ali Samii and Abraham Lieberman and Nausieda, \{Paul A.\} and Calne, \{Donald B.\} and Breakefield, \{Xandra O.\} and Christine Klein and Stoessl, \{A. Jon\}",

year = "2002",

month = jul,

day = "1",

doi = "10.1002/mds.10133",

language = "English",

volume = "17",

pages = "789--794",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley \& Sons Inc.",

number = "4",

}

TY - JOUR

T1 - [18F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism

AU - Pal, Pramod K.

AU - Leung, Joanne

AU - Hedrich, Katya

AU - Samii, Ali

AU - Lieberman, Abraham

AU - Nausieda, Paul A.

AU - Calne, Donald B.

AU - Breakefield, Xandra O.

AU - Klein, Christine

AU - Stoessl, A. Jon

PY - 2002/7/1

Y1 - 2002/7/1

N2 - There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of 18F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.

AB - There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of 18F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.

UR - https://www.scopus.com/pages/publications/18744399634

U2 - 10.1002/mds.10133

DO - 10.1002/mds.10133

M3 - Journal articles

C2 - 12210877

AN - SCOPUS:18744399634

SN - 0885-3185

VL - 17

SP - 789

EP - 794

JO - Movement Disorders

JF - Movement Disorders

IS - 4

ER -

[¹⁸F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this