[18F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism

Pramod K. Pal; Joanne Leung; Katya Hedrich; Ali Samii; Abraham Lieberman; Paul A. Nausieda; Donald B. Calne; Xandra O. Breakefield; Christine Klein; A. Jon Stoessl

doi:10.1002/mds.10133

[¹⁸F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism

Pramod K. Pal, Joanne Leung, Katya Hedrich, Ali Samii, Abraham Lieberman, Paul A. Nausieda, Donald B. Calne, Xandra O. Breakefield, Christine Klein, A. Jon Stoessl^*

^*Corresponding author for this work

Institute of Neurogenetics

9 Citations (Scopus)

Abstract

There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of ¹⁸F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.

Original language	English
Journal	Movement Disorders
Volume	17
Issue number	4
Pages (from-to)	789-794
Number of pages	6
ISSN	0885-3185
DOIs	https://doi.org/10.1002/mds.10133
Publication status	Published - 01.07.2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/mds.10133

Cite this

@article{efba673e72c34f409b49f75fdcedf60d,

title = "[18F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism",

abstract = "There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of 18F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.",

author = "Pal, {Pramod K.} and Joanne Leung and Katya Hedrich and Ali Samii and Abraham Lieberman and Nausieda, {Paul A.} and Calne, {Donald B.} and Breakefield, {Xandra O.} and Christine Klein and Stoessl, {A. Jon}",

year = "2002",

month = jul,

day = "1",

doi = "10.1002/mds.10133",

language = "English",

volume = "17",

pages = "789--794",

journal = "Movement Disorders",

issn = "0885-3185",

number = "4",

}

TY - JOUR

T1 - [18F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism

AU - Pal, Pramod K.

AU - Leung, Joanne

AU - Hedrich, Katya

AU - Samii, Ali

AU - Lieberman, Abraham

AU - Nausieda, Paul A.

AU - Calne, Donald B.

AU - Breakefield, Xandra O.

AU - Klein, Christine

AU - Stoessl, A. Jon

PY - 2002/7/1

Y1 - 2002/7/1

N2 - There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of 18F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.

AB - There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of 18F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.

UR - http://www.scopus.com/inward/record.url?scp=18744399634&partnerID=8YFLogxK

U2 - 10.1002/mds.10133

DO - 10.1002/mds.10133

M3 - Journal articles

C2 - 12210877

AN - SCOPUS:18744399634

SN - 0885-3185

VL - 17

SP - 789

EP - 794

JO - Movement Disorders

JF - Movement Disorders

IS - 4

ER -

[¹⁸F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this