TY - JOUR
T1 - Sulfur mustard skin lesions: A systematic review on pathomechanisms, treatment options and future research directions
AU - Rose, Dorothee
AU - Schmidt, Annette
AU - Brandenburger, Matthias
AU - Sturmheit, Tabea
AU - Zille, Marietta
AU - Boltze, Johannes
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Sulfur mustard (SM) is a chemical warfare, which has been used for one hundred years. However, its exact pathomechanisms are still incompletely understood and there is no specific therapy available so far. In this systematic review, studies published between January 2000 and July 2017 involving pathomechanisms and experimental treatments of SM-induced skin lesions were analyzed to summarize current knowledge on SM pathology, to provide an overview on novel treatment options, and to identify promising targets for future research to more effectively counter SM effects. We suggest that future studies should focus on (I) systemic effects of SM intoxication due to its distribution throughout the body, (II) removal of SM depots that continuously release active compound contributing to chronic skin damage, and (III) therapeutic options that counteract the pleiotropic effects of SM.
AB - Sulfur mustard (SM) is a chemical warfare, which has been used for one hundred years. However, its exact pathomechanisms are still incompletely understood and there is no specific therapy available so far. In this systematic review, studies published between January 2000 and July 2017 involving pathomechanisms and experimental treatments of SM-induced skin lesions were analyzed to summarize current knowledge on SM pathology, to provide an overview on novel treatment options, and to identify promising targets for future research to more effectively counter SM effects. We suggest that future studies should focus on (I) systemic effects of SM intoxication due to its distribution throughout the body, (II) removal of SM depots that continuously release active compound contributing to chronic skin damage, and (III) therapeutic options that counteract the pleiotropic effects of SM.
UR - http://www.scopus.com/inward/record.url?scp=85044867742&partnerID=8YFLogxK
U2 - 10.1016/j.toxlet.2017.11.039
DO - 10.1016/j.toxlet.2017.11.039
M3 - Journal articles
C2 - 29203275
AN - SCOPUS:85044867742
VL - 293
SP - 82
EP - 90
JO - Toxicology Letters
JF - Toxicology Letters
SN - 0378-4274
ER -