Suicide Prevention by Lithium (SUPLI) - Challenges of a multi-center prospective study

Erik Lauterbach*, Bernd Ahrens, Werner Felber, Bruno Muller-Oerlinghausen, Birgit Kilb, Gerd Bischof, Isabella Heuser, Petra Werner, Barbara Hawellek, Wolfgang Maier, Ute Lewitzka, Oliver Pogarell, Ulrich Hegerl, Thomas Bronisch, Kneginja Richter, Günther Niklewski, Andreas Broocks, Fritz Hohagen

*Corresponding author for this work
15 Citations (Scopus)


Several studies have shown that there is a significantly increased risk of suicide related mortality in patients with a positive history of suicide attempts. The SUPLI-Study is the first prospective, randomized, double blind, placebo controlled multi-center trial focusing on the proposed suicide preventive effects of lithium in patients with suicidal behavior but not suffering from bipolar disorder or recurrent major depressive disorder. Patients with a recent history of a suicide attempt are treated with lithium versus placebo during a 12 month period. The hypothesis is that lithium treatment will lead to a 50% reduction of suicidal behavior. The protocol of the study and preliminary results an presented.

Original languageEnglish
JournalArchives of Suicide Research
Issue number1
Pages (from-to)27-34
Number of pages8
Publication statusPublished - 2005

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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