TY - JOUR
T1 - Subtyping of polyposis nasi: phenotypes, endotypes and comorbidities
AU - Koennecke, Michael
AU - Klimek, Ludger
AU - Mullol, Joaquim
AU - Gevaert, Philippe
AU - Wollenberg, Barbara
N1 - Publisher Copyright:
© 2018, The Author(s).
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Background: Chronic rhinosinusitis (CRS) is a heterogeneous, multifactorial inflammatory disease of the nasal and paranasal mucosa. It has not been possible to date to develop an internationally standardized, uniform classification for this disorder. A phenotype classification according to CRS with (CRSwNP) and without polyposis (CRSsNP) is usually made. However, a large number of studies have shown that there are also different endotypes of CRS within these phenotypes, with different pathophysiologies of chronic inflammation of the nasal mucosa. This review describes the central immunological processes in nasal polyps, as well as the impact of related diseases on the inflammatory profile of nasal polyps. Materials and methods: The current knowledge on the immunological and molecular processes of CRS, in particular CRSwNP and its classification into specific endotypes, was put together by means of a structured literature search in Medline, PubMed, the national and international guideline registers, and the Cochrane Library. Results: Based on the current literature, the different immunological processes in CRS and nasal polyps were elaborated and a graphical representation in the form of an immunological network developed. In addition, different inflammatory profiles can be found in CRSwNP depending on related diseases, such as bronchial asthma, cystic fibrosis (CF), or NASID-Exacerbated Respiratory Disease (N‑ERD). Conclusion: The identification of different endotypes of CRSwNP may help to improvediagnostics and develop novel individual treatment approaches in CRSwNP.
AB - Background: Chronic rhinosinusitis (CRS) is a heterogeneous, multifactorial inflammatory disease of the nasal and paranasal mucosa. It has not been possible to date to develop an internationally standardized, uniform classification for this disorder. A phenotype classification according to CRS with (CRSwNP) and without polyposis (CRSsNP) is usually made. However, a large number of studies have shown that there are also different endotypes of CRS within these phenotypes, with different pathophysiologies of chronic inflammation of the nasal mucosa. This review describes the central immunological processes in nasal polyps, as well as the impact of related diseases on the inflammatory profile of nasal polyps. Materials and methods: The current knowledge on the immunological and molecular processes of CRS, in particular CRSwNP and its classification into specific endotypes, was put together by means of a structured literature search in Medline, PubMed, the national and international guideline registers, and the Cochrane Library. Results: Based on the current literature, the different immunological processes in CRS and nasal polyps were elaborated and a graphical representation in the form of an immunological network developed. In addition, different inflammatory profiles can be found in CRSwNP depending on related diseases, such as bronchial asthma, cystic fibrosis (CF), or NASID-Exacerbated Respiratory Disease (N‑ERD). Conclusion: The identification of different endotypes of CRSwNP may help to improvediagnostics and develop novel individual treatment approaches in CRSwNP.
UR - http://www.scopus.com/inward/record.url?scp=85043347570&partnerID=8YFLogxK
U2 - 10.1007/s40629-017-0048-5
DO - 10.1007/s40629-017-0048-5
M3 - Scientific review articles
AN - SCOPUS:85043347570
SN - 2197-0378
VL - 27
SP - 56
EP - 65
JO - Allergo Journal International
JF - Allergo Journal International
IS - 2
ER -