Subepidermal blasenbildende autoimmundermatose mit linearen ablagerungen von IgA und IgG

Translated title of the contribution: Autoimmune subepidermal bullous disease with linear deposits of IgA and IgG

Ellen Kersting*, M. Goebeler, H. Hamm, Ch Rose, D. Zillikens, Eva B. Bröcker

*Corresponding author for this work
    2 Citations (Scopus)

    Abstract

    A 29-year-old female patient with an autoimmune subepidermal blistering disease had linear deposits of both IgA and IgG at the basement membrane zone. Clinically, the patient presented with tense blisters on the face, trunk, extremities and oral mucosa. Histologically, we found a subepidermal blister formation and a predominantly neutrophilic infiltrate. Direct immunofluorescence showed linear deposits of IgA along the basement membrane zone, as well as linear deposits of IgG and C3 as typically found in bullous pemphigoid. Indirect immunofluorescence demonstrated circulating IgA and IgG autoantibodies. This case extends previous reports on a subgroup of patients with subepidermal blistering diseases characterized by the presence of both IgA and IgG anti-basement membrane antibodies. These patients reveal clinical, histological and immunopathological features of linear IgA disease and bullous pemphigoid.

    Translated title of the contributionAutoimmune subepidermal bullous disease with linear deposits of IgA and IgG
    Original languageGerman
    JournalHautarzt
    Volume51
    Issue number5
    Pages (from-to)340-344
    Number of pages5
    ISSN0017-8470
    DOIs
    Publication statusPublished - 05.2000

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