Structure of the X (ADRP) domain of nsp3 from feline coronavirus

Justyna A. Wojdyla, Ioannis Manolaridis, Eric J. Snijder, Alexander E. Gorbalenya, Bruno Coutard, Yvonne Piotrowski, Rolf Hilgenfeld, Paul A. Tucker

11 Citations (Scopus)


The structure of the X (or ADRP) domain of a pathogenic variant of feline coronavirus (FCoV) has been determined in tetragonal and cubic crystal forms to 3.1 and 2.2 Å resolution, respectively. In the tetragonal crystal form, glycerol-3-phos-phate was observed in the ADP-ribose-binding site. Both crystal forms contained large solvent channels and had a solvent content of higher than 70%. Only very weak binding of this domain to ADP-ribose was detected in vitro. However, the structure with ADP-ribose bound was determined in the cubic crystal form at 3.9 Å resolution. The structure of the FCoV X domain had the expected macro-domain fold and is the first structure of this domain from a coronavirus belonging to subgroup 1a.

Original languageEnglish
JournalActa Crystallographica Section D: Biological Crystallography
Issue number12
Pages (from-to)1292-1300
Number of pages9
Publication statusPublished - 18.12.2009

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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