Abstract
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases worldwide. Formation of amyloid plaques consisting of amyloid-β peptides (Aβ) is one of the hallmarks of AD. Several lines of evidence have shown a correlation between the Aβ aggregation and the disease development. Extensive research has been conducted with the aim to reveal the structures of the neurotoxic Aβ aggregates. However, the exact structure of pathological aggregates and mechanism of the disease still remains elusive due to complexity of the occurring processes and instability of various disease-relevant Aβ species. In this article we review up-to-date structural knowledge about amyloid-β peptides, focusing on data acquired using solution and solid state NMR techniques. Furthermore, we discuss implications from these structural studies on the mechanisms of aggregation and neurotoxicity.
| Original language | English |
|---|---|
| Journal | Biochimie |
| Volume | 140 |
| Pages (from-to) | 176-192 |
| Number of pages | 17 |
| ISSN | 0300-9084 |
| DOIs | |
| Publication status | Published - 09.2017 |
Funding
The work of J.P is also funded by Deutsche Forschungsgemeinschaft/Germany (DFG PA930/9, DFG PA930/12); Leibniz Society/Germany (SAW-2015-IPB-2); HelseS?/Norway (2016062); Norsk forskningsr?det/Norway (246392, 247179 (NeuroGeM), 248772, 251290); Horizon 2020/European Union (609020 (Scientia Fellows), 643417 (PROP-AD)). NeuroGeM is an EU Joint Programme - Neurodegenerative Disease Research (JPND) project. The project is supported through the following funding organizations under the aegis of JPND - www.jpnd.eu (CIHR ? Canada, BMBF ? Germany, NRF #247179 ? Norway, ZonMW ? The Netherlands). Scientia Fellows: The research has also received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-COFUND) under grant agreement No 609020.
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
