Structural insights into hepatitis C virus neutralization

Luisa J. Ströh; Thomas Krey

doi:10.1016/j.coviro.2023.101316

Structural insights into hepatitis C virus neutralization

Luisa J. Ströh, Thomas Krey

Institute of Biochemistry

Hannover Medical School

1 Citation (Scopus)

Abstract

Inspite of the available antiviral therapy, hepatitis C virus (HCV) remains a global health burden and a prophylactic vaccine would help to eliminate the risk to develop chronic liver diseases. Structural insights into the function of the glycoproteins E1 and E2 in virus entry and the interplay with the host's humoral immune response are key for informed vaccine development. We review recently reported structural insights into receptor binding of HCV glycoproteins and the assembly of an intact membrane-bound E1–E2 heterodimer. These data are used together with available functional data to draw a simplified model of virus entry, which highlights gaps in our current knowledge that warrant further research to fully understand this process at the atomic level.

Original language	English
Article number	101316
Journal	Current Opinion in Virology
Volume	60
ISSN	1879-6257
DOIs	https://doi.org/10.1016/j.coviro.2023.101316
Publication status	Published - 06.2023

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)
Centers: Center for Structural and Cell Biology (CSCM/ZMSZ)

DFG Research Classification Scheme

204-04 Virology
201-04 Structural Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.coviro.2023.101316

Cite this

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title = "Structural insights into hepatitis C virus neutralization",

abstract = "Inspite of the available antiviral therapy, hepatitis C virus (HCV) remains a global health burden and a prophylactic vaccine would help to eliminate the risk to develop chronic liver diseases. Structural insights into the function of the glycoproteins E1 and E2 in virus entry and the interplay with the host's humoral immune response are key for informed vaccine development. We review recently reported structural insights into receptor binding of HCV glycoproteins and the assembly of an intact membrane-bound E1–E2 heterodimer. These data are used together with available functional data to draw a simplified model of virus entry, which highlights gaps in our current knowledge that warrant further research to fully understand this process at the atomic level.",

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AU - Krey, Thomas

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N2 - Inspite of the available antiviral therapy, hepatitis C virus (HCV) remains a global health burden and a prophylactic vaccine would help to eliminate the risk to develop chronic liver diseases. Structural insights into the function of the glycoproteins E1 and E2 in virus entry and the interplay with the host's humoral immune response are key for informed vaccine development. We review recently reported structural insights into receptor binding of HCV glycoproteins and the assembly of an intact membrane-bound E1–E2 heterodimer. These data are used together with available functional data to draw a simplified model of virus entry, which highlights gaps in our current knowledge that warrant further research to fully understand this process at the atomic level.

AB - Inspite of the available antiviral therapy, hepatitis C virus (HCV) remains a global health burden and a prophylactic vaccine would help to eliminate the risk to develop chronic liver diseases. Structural insights into the function of the glycoproteins E1 and E2 in virus entry and the interplay with the host's humoral immune response are key for informed vaccine development. We review recently reported structural insights into receptor binding of HCV glycoproteins and the assembly of an intact membrane-bound E1–E2 heterodimer. These data are used together with available functional data to draw a simplified model of virus entry, which highlights gaps in our current knowledge that warrant further research to fully understand this process at the atomic level.

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DO - 10.1016/j.coviro.2023.101316

M3 - Scientific review articles

C2 - 37001334

AN - SCOPUS:85151275276

SN - 1879-6257

VL - 60

JO - Current Opinion in Virology

JF - Current Opinion in Virology

M1 - 101316

ER -

Structural insights into hepatitis C virus neutralization

Abstract

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

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