Structural brain abnormalities in cervical dystonia

Tino Prell*, Thomas Peschel, Bernadette Köhler, Martin H. Bokemeyer, Reinhard Dengler, Albrecht Günther, Julian Grosskreutz

*Corresponding author for this work
40 Citations (Scopus)


Background: Idiopathic cervical dystonia is characterized by involuntary spasms, tremors or jerks. It is not restricted to a disturbance in the basal ganglia system because non-conventional voxel-based MRI morphometry (VBM) and diffusion tensor imaging (DTI) have detected numerous regional changes in the brains of patients. In this study scans of 24 patients with cervical dystonia and 24 age-and sex-matched controls were analysed using VBM, DTI and magnetization transfer imaging (MTI) using a voxel-based approach and a region-of-interest analysis. Results were correlated with UDRS, TWSTRS and disease duration. Results: We found structural alterations in the basal ganglia; thalamus; motor cortex; premotor cortex; frontal, temporal and parietal cortices; visual system; cerebellum and brainstem of the patients with dystonia. Conclusions: Cervical dystonia is a multisystem disease involving several networks such as the motor, sensory and visual systems.

Original languageEnglish
Article number123
JournalBMC Neuroscience
Publication statusPublished - 16.10.2013
Externally publishedYes

Research Areas and Centers

  • Centers: Center for Neuromuscular Diseases


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