Stromal niches, plasma cell differentiation and survival

Katrin Moser; Koji Tokoyoda; Andreas Radbruch; Ian MacLennan; Rudolf A. Manz

doi:10.1016/j.coi.2006.03.004

Stromal niches, plasma cell differentiation and survival

Katrin Moser^*, Koji Tokoyoda, Andreas Radbruch, Ian MacLennan, Rudolf A. Manz

^*Corresponding author for this work

Institute of Systemic Inflammation Research

127 Citations (Scopus)

Abstract

Contacts made with other cells and stroma have a major impact on proliferation, differentiation, survival, migration and immunoglobulin class switching of plasma cell precursors as well as on the lifespan of the antibody-secreting cells. Induction of tissue-specific chemokine receptors and adhesion molecules directs migratory plasma cell precursors to tissues close to those in which the original immune stimulation occurred. This mechanism focuses the production of specific antibodies within a particular type of tissue, thus providing a means for the most efficient protection against tissue-specific pathogens. Relocation does not apply to long-lived plasma cells responsible for sustained titers of high-affinity systemic antibody. These are formed in germinal centers and migrate to specific niches in the bone marrow that support their further differentiation and long-term survival.

Original language	English
Journal	Current Opinion in Immunology
Volume	18
Issue number	3
Pages (from-to)	265-270
Number of pages	6
ISSN	0952-7915
DOIs	https://doi.org/10.1016/j.coi.2006.03.004
Publication status	Published - 06.2006

Funding

This work was supported by the German Research Foundation grant numbers MA 2273/4-1 and KFG 105.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.coi.2006.03.004

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title = "Stromal niches, plasma cell differentiation and survival",

abstract = "Contacts made with other cells and stroma have a major impact on proliferation, differentiation, survival, migration and immunoglobulin class switching of plasma cell precursors as well as on the lifespan of the antibody-secreting cells. Induction of tissue-specific chemokine receptors and adhesion molecules directs migratory plasma cell precursors to tissues close to those in which the original immune stimulation occurred. This mechanism focuses the production of specific antibodies within a particular type of tissue, thus providing a means for the most efficient protection against tissue-specific pathogens. Relocation does not apply to long-lived plasma cells responsible for sustained titers of high-affinity systemic antibody. These are formed in germinal centers and migrate to specific niches in the bone marrow that support their further differentiation and long-term survival.",

author = "Katrin Moser and Koji Tokoyoda and Andreas Radbruch and Ian MacLennan and Manz, \{Rudolf A.\}",

note = "Funding Information: This work was supported by the German Research Foundation grant numbers MA 2273/4-1 and KFG 105. ",

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language = "English",

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AU - Moser, Katrin

AU - Tokoyoda, Koji

AU - Radbruch, Andreas

AU - MacLennan, Ian

AU - Manz, Rudolf A.

N1 - Funding Information: This work was supported by the German Research Foundation grant numbers MA 2273/4-1 and KFG 105.

PY - 2006/6

Y1 - 2006/6

N2 - Contacts made with other cells and stroma have a major impact on proliferation, differentiation, survival, migration and immunoglobulin class switching of plasma cell precursors as well as on the lifespan of the antibody-secreting cells. Induction of tissue-specific chemokine receptors and adhesion molecules directs migratory plasma cell precursors to tissues close to those in which the original immune stimulation occurred. This mechanism focuses the production of specific antibodies within a particular type of tissue, thus providing a means for the most efficient protection against tissue-specific pathogens. Relocation does not apply to long-lived plasma cells responsible for sustained titers of high-affinity systemic antibody. These are formed in germinal centers and migrate to specific niches in the bone marrow that support their further differentiation and long-term survival.

AB - Contacts made with other cells and stroma have a major impact on proliferation, differentiation, survival, migration and immunoglobulin class switching of plasma cell precursors as well as on the lifespan of the antibody-secreting cells. Induction of tissue-specific chemokine receptors and adhesion molecules directs migratory plasma cell precursors to tissues close to those in which the original immune stimulation occurred. This mechanism focuses the production of specific antibodies within a particular type of tissue, thus providing a means for the most efficient protection against tissue-specific pathogens. Relocation does not apply to long-lived plasma cells responsible for sustained titers of high-affinity systemic antibody. These are formed in germinal centers and migrate to specific niches in the bone marrow that support their further differentiation and long-term survival.

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DO - 10.1016/j.coi.2006.03.004

M3 - Scientific review articles

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SP - 265

EP - 270

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

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ER -

Stromal niches, plasma cell differentiation and survival

Abstract

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UN SDGs

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