Stromal niches, plasma cell differentiation and survival

Katrin Moser*, Koji Tokoyoda, Andreas Radbruch, Ian MacLennan, Rudolf A. Manz

*Corresponding author for this work
114 Citations (Scopus)


Contacts made with other cells and stroma have a major impact on proliferation, differentiation, survival, migration and immunoglobulin class switching of plasma cell precursors as well as on the lifespan of the antibody-secreting cells. Induction of tissue-specific chemokine receptors and adhesion molecules directs migratory plasma cell precursors to tissues close to those in which the original immune stimulation occurred. This mechanism focuses the production of specific antibodies within a particular type of tissue, thus providing a means for the most efficient protection against tissue-specific pathogens. Relocation does not apply to long-lived plasma cells responsible for sustained titers of high-affinity systemic antibody. These are formed in germinal centers and migrate to specific niches in the bone marrow that support their further differentiation and long-term survival.

Original languageEnglish
JournalCurrent Opinion in Immunology
Issue number3
Pages (from-to)265-270
Number of pages6
Publication statusPublished - 06.2006


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