Abstract
In the last fifteen years it has become apparent that tissue-resident mesenchymal cells such as fibroblasts, which are the structural elements of all organs, play a cardinal role in the pathology of immune-mediated inflammatory diseases. We now know that all fibroblasts originate from universal pan-organ cellular ancestors and that they are diversified into more specific subsets according to the functional needs of their home tissue-and its activation state. In arthritis, a plethora of activated joint-resident and migrating fibroblast types have been recently described that are central for pathogenesis and persistence of inflammatory joint-disease. Here we provide a current overview on the multiple inflammatory and immune-related functions of fibroblasts and how they could be curbed to induce long-lasting abatement of disease.
| Original language | English |
|---|---|
| Journal | Current Opinion in Immunology |
| Volume | 74 |
| Pages (from-to) | 92-99 |
| Number of pages | 8 |
| ISSN | 0952-7915 |
| DOIs | |
| Publication status | Published - 02.2022 |
Funding
This work was supported by the German Research Foundation (DFG, FOR2886-TP08 and CRC1181-B03 ). Figures were created with Biorender.com .
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
- Centers: Center for Research on Inflammation of the Skin (CRIS)
DFG Research Classification Scheme
- 2.21-05 Immunology
