Streptococcus pneumoniae-induced regulation of cyclooxygenase-2 in human lung tissue

Kolja V. Szymanski, Mario Toennies, Anne Becher, Diana Fatykhova, Philippe D. N'Guessan, Birgitt Gutbier, Frederick Klauschen, Frank Neuschaefer-Rube, Paul Schneider, Jens Rueckert, Jens Neudecker, Torsten T. Bauer, Klaus Dalhoff, Daniel Drom̈ann, Achim D. Gruber, Olivia Kershaw, Bettina Temmesfeld-Wollbrueck, Norbert Suttorp, Stefan Hippenstiel, Andreas C. Hocke*

*Corresponding author for this work
19 Citations (Scopus)


The majority of cases of community-acquired pneumonia are caused by Streptococcus pneumoniae and most studies on pneumococcal host interaction are based on cell culture or animal experiments. Thus, little is known about infections in human lung tissue. Cyclooxygenase-2 and its metabolites play an important regulatory role in lung inflammation. Therefore, we established a pneumococcal infection model on human lung tissue demonstrating mitogen-activated protein kinase (MAPK)-dependent induction of cyclooxygenase-2 and its related metabolites. In addition to alveolar macrophages and the vascular endothelium, cyclooxygenase-2 was upregulated in alveolar type II but not type I epithelial cells, which was confirmed in lungs of patients suffering from acute pneumonia. Moreover, we demonstrated the expression profile of all four E prostanoid receptors at the mRNA level and showed functionality of the E prostanoid4receptor by cyclic adenosine monophosphate production. Additionally, in comparison to previous studies, cyclooxygenase-2/prostaglandin E2 related pro- and anti-inflammatory mediator regulation was partly confirmed in human lung tissue after pneumococcal infection. Overall, cell type-specific and MAPK-dependent cyclooxygenase-2 expression and prostaglandin E2 formation in human lung tissue may play an important role in the early phase of pneumococcal infections. Copyright

Original languageEnglish
JournalEuropean Respiratory Journal
Issue number6
Pages (from-to)1458-1467
Number of pages10
Publication statusPublished - 01.12.2012

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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