Abstract
Primordial germ cells develop into oocytes and sperm cells. These cells are useful resources in reproductive biology and regenerative medicine. The mesenchymal stem cells (MSCs) have been examined for in vitro production of primordial germ cell-like cells (PGLCs). This study aimed to summarize the existing protocols for MSCs differentiation into PGLCs. In limited identified studies, various models of MSCs, including those derived from adipose tissue, bone marrow, and Wharton's jelly, have been successfully differentiated in to PGLCs. Although the protocols of specification induction are basically very similar, they have been adjusted to the mesenchymal cell type and the species of origin. The availability of MSCs has made it possible to customize conditions for their differentiation into PGLCs in several models, including humans. Refining germ cell-related signaling pathways during induced differentiation of MSCs will help to define extension to the protocols for PGLCs production.
| Original language | English |
|---|---|
| Journal | Cell Journal |
| Volume | 24 |
| Issue number | 8 |
| Pages (from-to) | 434-441 |
| Number of pages | 8 |
| ISSN | 2228-5806 |
| DOIs | |
| Publication status | Published - 08.2022 |
Funding
This study was supported by Endocrine Research Center (grant No. 59420) and Faculty of Advanced Medical Sciences at Tabriz University of Medical Sciences, Iran. Authors declare no conflict of interest in this study. This study was supported by Endocrine Research Center
| Funders | Funder number |
|---|---|
| Department of Growth and Reproduction and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC) | 59420 |
| Faculty of Advanced Medical Sciences at Tabriz University of Medical Sciences |
Research Areas and Centers
- Centers: Center for Pre-Implantation Diagnostics (PID)
