TY - JOUR
T1 - Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells
T2 - A Review
AU - Fayezi, Shabnam
AU - Fayyazpour, Parisa
AU - Norouzi, Zahra
AU - Mehdizadeh, Amir
N1 - Publisher Copyright:
© 2022 Royan Institute (ACECR). All rights reserved.
PY - 2022/8
Y1 - 2022/8
N2 - Primordial germ cells develop into oocytes and sperm cells. These cells are useful resources in reproductive biology and regenerative medicine. The mesenchymal stem cells (MSCs) have been examined for in vitro production of primordial germ cell-like cells (PGLCs). This study aimed to summarize the existing protocols for MSCs differentiation into PGLCs. In limited identified studies, various models of MSCs, including those derived from adipose tissue, bone marrow, and Wharton's jelly, have been successfully differentiated in to PGLCs. Although the protocols of specification induction are basically very similar, they have been adjusted to the mesenchymal cell type and the species of origin. The availability of MSCs has made it possible to customize conditions for their differentiation into PGLCs in several models, including humans. Refining germ cell-related signaling pathways during induced differentiation of MSCs will help to define extension to the protocols for PGLCs production.
AB - Primordial germ cells develop into oocytes and sperm cells. These cells are useful resources in reproductive biology and regenerative medicine. The mesenchymal stem cells (MSCs) have been examined for in vitro production of primordial germ cell-like cells (PGLCs). This study aimed to summarize the existing protocols for MSCs differentiation into PGLCs. In limited identified studies, various models of MSCs, including those derived from adipose tissue, bone marrow, and Wharton's jelly, have been successfully differentiated in to PGLCs. Although the protocols of specification induction are basically very similar, they have been adjusted to the mesenchymal cell type and the species of origin. The availability of MSCs has made it possible to customize conditions for their differentiation into PGLCs in several models, including humans. Refining germ cell-related signaling pathways during induced differentiation of MSCs will help to define extension to the protocols for PGLCs production.
UR - http://www.scopus.com/inward/record.url?scp=85138642540&partnerID=8YFLogxK
U2 - 10.22074/CELLJ.2022.8087
DO - 10.22074/CELLJ.2022.8087
M3 - Scientific review articles
AN - SCOPUS:85138642540
SN - 2228-5806
VL - 24
SP - 434
EP - 441
JO - Cell Journal
JF - Cell Journal
IS - 8
ER -