Stimulation augments spike sequence replay and memory consolidation during slow-wave sleep

Yina Wei, Giri P. Krishnan, X. Lisa Marshall, Thomas Martinetz, Maxim Bazhenov*

*Corresponding author for this work
3 Citations (Scopus)

Abstract

Newly acquired memory traces are spontaneously reactivated during slow-wave sleep (SWS), leading to the consolidation of recent memories. Empirical studies found that sensory stimulation during SWS can selectively enhance memory consolidation with the effect depending on the phase of stimulation. In this new study, we aimed to understand the mechanisms behind the role of sensory stimulation on memory consolidation using computational models implementing effects of neuromodulators to simulate transitions between awake and SWS sleep, and synaptic plasticity to allow the change of synaptic connections due to the training in awake or replay during sleep. We found that when closed-loop stimulation was applied during the Down states of sleep slow oscillation, particularly right before the transition from Down to Up state, it significantly affected the spatiotemporal pattern of the slow waves and maximized memory replay. In contrast, when the stimulation was presented during the Up states, it did not have a significant impact on the slow waves or memory performance after sleep. For multiple memories trained in awake, presenting stimulation cues associated with specific memory trace could selectively augment replay and enhance consolidation of that memory and interfere with consolidation of the others (particularly weak) memories. Our study proposes a synaptic-level mechanism of how memory consolidation is affected by sensory stimulation during sleep.

Original languageEnglish
JournalJournal of Neuroscience
Volume40
Issue number4
Pages (from-to)811-824
Number of pages14
ISSN0270-6474
DOIs
Publication statusPublished - 22.01.2020

Research Areas and Centers

  • Centers: Center for Artificial Intelligence Luebeck (ZKIL)
  • Research Area: Intelligent Systems

DFG Research Classification Scheme

  • 201-07 Bioinformatics and Theoretical Biology
  • Computational Neuroscience

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