Stem cells in squamous head and neck cancer

Andreas E. Albers; Chao Chen; Beate Köberle; Xu Qian; Jens P. Klussmann; Barbara Wollenberg; Andreas M. Kaufmann

doi:10.1016/j.critrevonc.2011.03.004

Stem cells in squamous head and neck cancer

Andreas E. Albers^*, Chao Chen, Beate Köberle, Xu Qian, Jens P. Klussmann, Barbara Wollenberg, Andreas M. Kaufmann

^*Corresponding author for this work

35 Citations (Scopus)

Abstract

The initiation and metastasis of head and neck squamous cell carcinomas (HNSCC) and other cancers have recently been related to the presence of cancer stem cells (CSC). CSC are cancer initiating, sustaining and are mostly quiescent. Specific markers that vary considerably depending on tumor type or tissue of origin characterize putative CSC. Compared to the bulk tumor mass, CSC are less sensitive to chemo- and radiotherapy and may also have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome of HNSCC which has two distinct etiologies: infection of epithelial stem cells by high-risk types of the human papillomavirus, or long-term tobacco and alcohol abuse. Recent knowledge on the role of CSC in HNSCC is reviewed and where necessary parallels to CSC of other origin are drawn to give a more comprehensive picture.

Original language	English
Journal	Critical Reviews in Oncology/Hematology
Volume	81
Issue number	3
Pages (from-to)	224-240
Number of pages	17
ISSN	1040-8428
DOIs	https://doi.org/10.1016/j.critrevonc.2011.03.004
Publication status	Published - 01.03.2012

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10.1016/j.critrevonc.2011.03.004

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abstract = "The initiation and metastasis of head and neck squamous cell carcinomas (HNSCC) and other cancers have recently been related to the presence of cancer stem cells (CSC). CSC are cancer initiating, sustaining and are mostly quiescent. Specific markers that vary considerably depending on tumor type or tissue of origin characterize putative CSC. Compared to the bulk tumor mass, CSC are less sensitive to chemo- and radiotherapy and may also have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome of HNSCC which has two distinct etiologies: infection of epithelial stem cells by high-risk types of the human papillomavirus, or long-term tobacco and alcohol abuse. Recent knowledge on the role of CSC in HNSCC is reviewed and where necessary parallels to CSC of other origin are drawn to give a more comprehensive picture.",

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AU - Albers, Andreas E.

AU - Chen, Chao

AU - Köberle, Beate

AU - Qian, Xu

AU - Klussmann, Jens P.

AU - Wollenberg, Barbara

AU - Kaufmann, Andreas M.

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N2 - The initiation and metastasis of head and neck squamous cell carcinomas (HNSCC) and other cancers have recently been related to the presence of cancer stem cells (CSC). CSC are cancer initiating, sustaining and are mostly quiescent. Specific markers that vary considerably depending on tumor type or tissue of origin characterize putative CSC. Compared to the bulk tumor mass, CSC are less sensitive to chemo- and radiotherapy and may also have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome of HNSCC which has two distinct etiologies: infection of epithelial stem cells by high-risk types of the human papillomavirus, or long-term tobacco and alcohol abuse. Recent knowledge on the role of CSC in HNSCC is reviewed and where necessary parallels to CSC of other origin are drawn to give a more comprehensive picture.

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Stem cells in squamous head and neck cancer

Abstract

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