Stand-alone Focal Impulse and Rotor Modulation (FIRM) ablation versus second-generation cryoballoon pulmonary vein isolation for paroxysmal atrial fibrillation

Roland R. Tilz*, Kivanc Yalin, Evgeny Lyan, Christian Hendrik Heeger, Michael Schlüter, Thomas Fink, Vanessa Sciacca, Spyridon Liosis, Karl Heinz Kuck, Sorin Ștefan Popescu, Kai Mortensen, Roza Meyer-Saraei, Charlotte Eitel, Julia Vogler

*Corresponding author for this work
3 Citations (Scopus)

Abstract

Introduction: Focal Impulse and Rotor Modulation (FIRM) guided catheter ablation aiming at stable rotors has been investigated as a treatment option in patients with atrial fibrillation (AF). The objective of this study was to compare the safety and efficacy of FIRM-guided ablation with second-generation cryoballoon pulmonary vein isolation (CB2-PVI) in paroxysmal AF. Methods: Consecutive patients (n = 22, mean age 60 ± 11 years, 59.1% of males) who were treated with a stand-alone FIRM-guided ablation were included in this retrospective single-center study. Procedural data and arrhythmia-free survival at 12 months were compared with n = 86 consecutive patients (mean age 62 ± 13 years, 62.4% of males) who received de-novo CB2-PVI. Results: Median procedure duration was significantly longer in the FIRM group than in the CB2-PVI group (152 [IQR 120–176] minutes vs. 122 [110–145] minutes; p =.031). One patient (1.2%) in the CB2-PVI group and five patients (22.7%) in the FIRM group had vascular access complications. Atrial tachyarrhythmias recurred in 15 patients in the FIRM group and 11 in the CB2-PVI group. Kaplan–Meier estimation of single-procedure arrhythmia-free survival at 12 months was 25% (95% confidence interval [CI] 6%–44%) in the FIRM group and 87% (95% CI 78%–96%) in the CB2-PVI group (p <.001). Repeat ablations were performed in 14/20 (70.0%) patients in the FIRM group and in 12/85 (14.1%) in the CB2-PVI group (p <.001). Conclusion: De novo ablation of AF using FIRM-guided AF ablation results in shorter arrhythmia-free survival after 12 months compared to CB2-PVI and a need for repeat ablation in the majority of patients to achieve stable sinus rhythm.

Original languageEnglish
JournalJournal of Cardiovascular Electrophysiology
Volume33
Issue number8
Pages (from-to)1678-1686
Number of pages9
ISSN1045-3873
DOIs
Publication statusPublished - 08.2022

Research Areas and Centers

  • Centers: Cardiological Center Luebeck (UHZL)

DFG Research Classification Scheme

  • 205-12 Cardiology, Angiology

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