TY - JOUR
T1 - Stand-alone emollient treatment reduces flares after discontinuation of topical steroid treatment in atopic dermatitis: A double-blind, randomized, vehicle-controlled, left-right comparison study
AU - Angelova-Fischer, Irena
AU - Rippke, Frank
AU - Richter, Daniel
AU - Filbry, Alexander
AU - Arrowitz, Craig
AU - Weber, Teresa
AU - Fischer, Tobias W.
AU - Zillikens, Detlef
PY - 2018/5
Y1 - 2018/5
N2 - Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications.
AB - Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications.
UR - http://www.scopus.com/inward/record.url?scp=85046083767&partnerID=8YFLogxK
U2 - 10.2340/00015555-2882
DO - 10.2340/00015555-2882
M3 - Journal articles
C2 - 29335742
AN - SCOPUS:85046083767
SN - 0001-5555
VL - 98
SP - 517
EP - 523
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 5
ER -