Spectroscopic studies on iron complexes of different anthracyclines in aprotic solvent systems

H. Drechsel; M. Fiallo; A. Garnier-Suillerot; B. F. Matzanke; V. Schünemann

doi:10.1021/ic0002723

Spectroscopic studies on iron complexes of different anthracyclines in aprotic solvent systems

H. Drechsel^*, M. Fiallo, A. Garnier-Suillerot, B. F. Matzanke, V. Schünemann

^*Corresponding author for this work

Institute of Physics

15 Citations (Scopus)

Abstract

The iron complexes of daunorubicin, idarubicin, pirarubicin, and doxorubicin were prepared in anhydrous DMF and studied by absorption, circular dichroism, Mössbauer, and EPR spectroscopy. Metal complexation was studied in titration series at different metal/ligand ratios. Optical spectroscopy indicates the existance of two different complex species, which were further characterized by EPR and Mössbauer experiments. Structural models for both complex species, differing in complexation mode and degree of oligomerization, are proposed.

Original language	English
Journal	Inorganic Chemistry
Volume	40
Issue number	21
Pages (from-to)	5324-5333
Number of pages	10
ISSN	0020-1669
DOIs	https://doi.org/10.1021/ic0002723
Publication status	Published - 08.10.2001

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abstract = "The iron complexes of daunorubicin, idarubicin, pirarubicin, and doxorubicin were prepared in anhydrous DMF and studied by absorption, circular dichroism, M{\"o}ssbauer, and EPR spectroscopy. Metal complexation was studied in titration series at different metal/ligand ratios. Optical spectroscopy indicates the existance of two different complex species, which were further characterized by EPR and M{\"o}ssbauer experiments. Structural models for both complex species, differing in complexation mode and degree of oligomerization, are proposed.",

author = "H. Drechsel and M. Fiallo and A. Garnier-Suillerot and Matzanke, {B. F.} and V. Sch{\"u}nemann",

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AU - Drechsel, H.

AU - Fiallo, M.

AU - Garnier-Suillerot, A.

AU - Matzanke, B. F.

AU - Schünemann, V.

PY - 2001/10/8

Y1 - 2001/10/8

N2 - The iron complexes of daunorubicin, idarubicin, pirarubicin, and doxorubicin were prepared in anhydrous DMF and studied by absorption, circular dichroism, Mössbauer, and EPR spectroscopy. Metal complexation was studied in titration series at different metal/ligand ratios. Optical spectroscopy indicates the existance of two different complex species, which were further characterized by EPR and Mössbauer experiments. Structural models for both complex species, differing in complexation mode and degree of oligomerization, are proposed.

AB - The iron complexes of daunorubicin, idarubicin, pirarubicin, and doxorubicin were prepared in anhydrous DMF and studied by absorption, circular dichroism, Mössbauer, and EPR spectroscopy. Metal complexation was studied in titration series at different metal/ligand ratios. Optical spectroscopy indicates the existance of two different complex species, which were further characterized by EPR and Mössbauer experiments. Structural models for both complex species, differing in complexation mode and degree of oligomerization, are proposed.

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EP - 5333

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 21

ER -

Spectroscopic studies on iron complexes of different anthracyclines in aprotic solvent systems

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