Speckle variance optical coherence tomography for imaging microcirculation

Dominico Klawitter, Dierck Hillmann, M Pieper, Philipp Steven, J Wenzel, Gereon Hüttmann


Non-invasive flow detection and in-vivo measurement are one of the most requested clinical applications for medical imaging modalities to investigate vascular pathologies and responsiveness to drug therapy. Implementing speckle variance calculation & visualization in a market-proven optical coherence tomography (OCT) system we demonstrate an angiography imaging algorithm that provides angle independent, depth-resolved flow measurement up to a capillary scale. The feasibility of quantitative flow analysis with speckle variance OCT (svOCT) is to be demonstrated by the evaluation with silicone phantom, animal and human probes, respectively. First results lead to the assumption that reliable access to quantified flow velocities with svOCT is not obtainable. However svOCT delivers high vascular contrast at minimal oversampling rates, being a simple implementation module and a beneficial extension to OCT systems in general.
Original languageEnglish
Title of host publicationStudent Conference Medical Engineering Science 2013
EditorsT. M. Buzug
Place of PublicationLübeck
PublisherGRIN Publishing
Publication date2013
ISBN (Print)978-3-656-38193-8
ISBN (Electronic)978-3-656-38192-1
Publication statusPublished - 2013
EventStudent Conference 2013 - Lübeck, Germany
Duration: 13.03.201314.03.2013


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