Specific recognition of proteins by array-bound hexanucleotides

Alessandra Mescalchin; Winfried Wünsche; Georg Sczakiel

doi:10.1002/anie.201003462

Specific recognition of proteins by array-bound hexanucleotides

Alessandra Mescalchin^*, Winfried Wünsche, Georg Sczakiel

^*Corresponding author for this work

Institute of Molecular Medicine

University of Kiel

4 Citations (Scopus)

Abstract

Maximum information density: The complete hexanucleotide sequence space can be immobilized on a chip. The binding of a number of proteins was profiled with this array of 4096 sequences, including fluorescently labeled forms of the HIV-2 and HIV-1 reverse transciptases (the consensus motif is shown in the picture). This new technique should aid in the search for pharmaceutical lead compunds.

Original language	English
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	5
Pages (from-to)	1052-1054
Number of pages	3
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201003462
Publication status	Published - 01.02.2011

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10.1002/anie.201003462

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abstract = "Maximum information density: The complete hexanucleotide sequence space can be immobilized on a chip. The binding of a number of proteins was profiled with this array of 4096 sequences, including fluorescently labeled forms of the HIV-2 and HIV-1 reverse transciptases (the consensus motif is shown in the picture). This new technique should aid in the search for pharmaceutical lead compunds.",

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AU - Wünsche, Winfried

AU - Sczakiel, Georg

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N2 - Maximum information density: The complete hexanucleotide sequence space can be immobilized on a chip. The binding of a number of proteins was profiled with this array of 4096 sequences, including fluorescently labeled forms of the HIV-2 and HIV-1 reverse transciptases (the consensus motif is shown in the picture). This new technique should aid in the search for pharmaceutical lead compunds.

AB - Maximum information density: The complete hexanucleotide sequence space can be immobilized on a chip. The binding of a number of proteins was profiled with this array of 4096 sequences, including fluorescently labeled forms of the HIV-2 and HIV-1 reverse transciptases (the consensus motif is shown in the picture). This new technique should aid in the search for pharmaceutical lead compunds.

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JO - Angewandte Chemie - International Edition

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Specific recognition of proteins by array-bound hexanucleotides

Abstract

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