Specific recognition of proteins by array-bound hexanucleotides

Alessandra Mescalchin*, Winfried Wünsche, Georg Sczakiel

*Corresponding author for this work
4 Citations (Scopus)


Maximum information density: The complete hexanucleotide sequence space can be immobilized on a chip. The binding of a number of proteins was profiled with this array of 4096 sequences, including fluorescently labeled forms of the HIV-2 and HIV-1 reverse transciptases (the consensus motif is shown in the picture). This new technique should aid in the search for pharmaceutical lead compunds.

Original languageEnglish
JournalAngewandte Chemie - International Edition
Issue number5
Pages (from-to)1052-1054
Number of pages3
Publication statusPublished - 01.02.2011


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