Species-Specific Functional Regions of the Green Alga Gamete Fusion Protein HAP2 Revealed by Structural Studies

Eduard Baquero; Juliette Fedry; Pierre Legrand; Thomas Krey; Felix A. Rey

doi:10.1016/j.str.2018.09.014

Species-Specific Functional Regions of the Green Alga Gamete Fusion Protein HAP2 Revealed by Structural Studies

Eduard Baquero, Juliette Fedry, Pierre Legrand, Thomas Krey, Felix A. Rey^*

^*Corresponding author for this work

Institute of Biochemistry

10 Citations (Scopus)

Abstract

Baquero et al. report the structure of the HAP2 gamete fusion protein of the Chlamydomonas reinhardtii alga, describing key elements required to bridge two opposite-type gametes and drive their fusion. Mutagenesis of these elements confirmed their membrane-interaction function. Additional specific HAP2 protein-protein interaction sites are described as potential fusion controls.

Original language	English
Journal	Structure
Volume	27
Issue number	1
Pages (from-to)	113-124.e4
ISSN	0969-2126
DOIs	https://doi.org/10.1016/j.str.2018.09.014
Publication status	Published - 02.01.2019

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10.1016/j.str.2018.09.014

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abstract = "Baquero et al. report the structure of the HAP2 gamete fusion protein of the Chlamydomonas reinhardtii alga, describing key elements required to bridge two opposite-type gametes and drive their fusion. Mutagenesis of these elements confirmed their membrane-interaction function. Additional specific HAP2 protein-protein interaction sites are described as potential fusion controls.",

author = "Eduard Baquero and Juliette Fedry and Pierre Legrand and Thomas Krey and Rey, {Felix A.}",

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AU - Rey, Felix A.

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AB - Baquero et al. report the structure of the HAP2 gamete fusion protein of the Chlamydomonas reinhardtii alga, describing key elements required to bridge two opposite-type gametes and drive their fusion. Mutagenesis of these elements confirmed their membrane-interaction function. Additional specific HAP2 protein-protein interaction sites are described as potential fusion controls.

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Species-Specific Functional Regions of the Green Alga Gamete Fusion Protein HAP2 Revealed by Structural Studies

Abstract

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