TY - JOUR
T1 - Spatiotemporal distribution of white matter lesions in relapsing-remitting and secondary progressive multiple sclerosis
AU - Filli, Lukas
AU - Hofstetter, Louis
AU - Kuster, Pascal
AU - Traud, Stefan
AU - Mueller-Lenke, Nicole
AU - Naegelin, Yvonne
AU - Kappos, Ludwig
AU - Gass, Achim
AU - Sprenger, Till
AU - Nichols, Thomas E.
AU - Vrenken, Hugo
AU - Barkhof, Frederik
AU - Polman, Chris
AU - Radue, Ernst Wilhelm
AU - Borgwardt, Stefan J.
AU - Bendfeldt, Kerstin
PY - 2012/11
Y1 - 2012/11
N2 - Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. MS lesions show a typical distribution pattern and primarily affect the white matter (WM) in the periventricular zone and in the centrum semiovale. Objective: To track lesion development during disease progression, we compared the spatiotemporal distribution patterns of lesions in relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS). Methods: We used T1 and T2 weighted MR images of 209 RRMS and 62 SPMS patients acquired on two different 1.5 Tesla MR scanners in two clinical centers followed up for 25 (± 1.7) months. Both cross-sectional and longitudinal differences in lesion distribution between RRMS and SPMS patients were analyzed with lesion probability maps (LPMs) and permutation-based inference. Results: MS lesions clustered around the lateral ventricles and in the centrum semiovale. Cross-sectionally, compared to RRMS patients, the SPMS patients showed a significantly higher regional probability of T1 hypointense lesions (p=0.03) in the callosal body, the corticospinal tract, and other tracts adjacent to the lateral ventricles, but not of T2 lesions (peak probabilities were RRMS: T1 9%, T2 18%; SPMS: T1 21%, T2 27%). No longitudinal changes of regional T1 and T2 lesion volumes between baseline and follow-up scan were found. Conclusion: The results suggest a particular vulnerability to neurodegeneration during disease progression in a number of WM tracts.
AB - Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. MS lesions show a typical distribution pattern and primarily affect the white matter (WM) in the periventricular zone and in the centrum semiovale. Objective: To track lesion development during disease progression, we compared the spatiotemporal distribution patterns of lesions in relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS). Methods: We used T1 and T2 weighted MR images of 209 RRMS and 62 SPMS patients acquired on two different 1.5 Tesla MR scanners in two clinical centers followed up for 25 (± 1.7) months. Both cross-sectional and longitudinal differences in lesion distribution between RRMS and SPMS patients were analyzed with lesion probability maps (LPMs) and permutation-based inference. Results: MS lesions clustered around the lateral ventricles and in the centrum semiovale. Cross-sectionally, compared to RRMS patients, the SPMS patients showed a significantly higher regional probability of T1 hypointense lesions (p=0.03) in the callosal body, the corticospinal tract, and other tracts adjacent to the lateral ventricles, but not of T2 lesions (peak probabilities were RRMS: T1 9%, T2 18%; SPMS: T1 21%, T2 27%). No longitudinal changes of regional T1 and T2 lesion volumes between baseline and follow-up scan were found. Conclusion: The results suggest a particular vulnerability to neurodegeneration during disease progression in a number of WM tracts.
UR - http://www.scopus.com/inward/record.url?scp=84862284430&partnerID=8YFLogxK
U2 - 10.1177/1352458512442756
DO - 10.1177/1352458512442756
M3 - Journal articles
C2 - 22495945
AN - SCOPUS:84862284430
SN - 1352-4585
VL - 18
SP - 1577
EP - 1584
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 11
ER -
