Source and component genes of a 6-200 Mb gene cluster in the house mouse

Dieter Weichenhan; Bärbel Kunze; Heinz Winking; Michel Van Geel; Kazutoyo Osoegawa; Pieter J. De Jong; Walther Traut

doi:10.1007/s00335-001-3015-9

Source and component genes of a 6-200 Mb gene cluster in the house mouse

Dieter Weichenhan^*, Bärbel Kunze, Heinz Winking, Michel Van Geel, Kazutoyo Osoegawa, Pieter J. De Jong, Walther Traut

^*Corresponding author for this work

Institute of Biology

21 Citations (Scopus)

Abstract

We identified and analyzed the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli. Sp100 is a nuclear dot gene; Csprs and Ifi75 are novel genes encoding a putative G-protein coupled receptor (GPCR) and a putative transcriptional coactivator, respectively. A fourth gene, Sp100-rs, occurs in M. musculus, but not in M. caroli. Sp100-rs is a chimeric gene which arose by fusion of Sp100 and Csprs copies. Sp100-rs and Ifi75 are components of a repeat cluster that extends over 6-200 Mb of the M. musculus genome. The Sp100-rs fusion gene arose only 1-2 million years ago and has become fixed and amplified in M. musculus. Although the gene is transcribed, it appears to have no function. The repeat cluster may have become fixed in the species as a "hitchhiker" in a "selective sweep".

Original language	English
Journal	Mammalian Genome
Volume	12
Issue number	8
Pages (from-to)	590-594
Number of pages	5
ISSN	0938-8990
DOIs	https://doi.org/10.1007/s00335-001-3015-9
Publication status	Published - 04.08.2001

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title = "Source and component genes of a 6-200 Mb gene cluster in the house mouse",

abstract = "We identified and analyzed the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli. Sp100 is a nuclear dot gene; Csprs and Ifi75 are novel genes encoding a putative G-protein coupled receptor (GPCR) and a putative transcriptional coactivator, respectively. A fourth gene, Sp100-rs, occurs in M. musculus, but not in M. caroli. Sp100-rs is a chimeric gene which arose by fusion of Sp100 and Csprs copies. Sp100-rs and Ifi75 are components of a repeat cluster that extends over 6-200 Mb of the M. musculus genome. The Sp100-rs fusion gene arose only 1-2 million years ago and has become fixed and amplified in M. musculus. Although the gene is transcribed, it appears to have no function. The repeat cluster may have become fixed in the species as a {"}hitchhiker{"} in a {"}selective sweep{"}.",

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T1 - Source and component genes of a 6-200 Mb gene cluster in the house mouse

AU - Weichenhan, Dieter

AU - Kunze, Bärbel

AU - Winking, Heinz

AU - Van Geel, Michel

AU - Osoegawa, Kazutoyo

AU - De Jong, Pieter J.

AU - Traut, Walther

PY - 2001/8/4

Y1 - 2001/8/4

N2 - We identified and analyzed the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli. Sp100 is a nuclear dot gene; Csprs and Ifi75 are novel genes encoding a putative G-protein coupled receptor (GPCR) and a putative transcriptional coactivator, respectively. A fourth gene, Sp100-rs, occurs in M. musculus, but not in M. caroli. Sp100-rs is a chimeric gene which arose by fusion of Sp100 and Csprs copies. Sp100-rs and Ifi75 are components of a repeat cluster that extends over 6-200 Mb of the M. musculus genome. The Sp100-rs fusion gene arose only 1-2 million years ago and has become fixed and amplified in M. musculus. Although the gene is transcribed, it appears to have no function. The repeat cluster may have become fixed in the species as a "hitchhiker" in a "selective sweep".

AB - We identified and analyzed the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli. Sp100 is a nuclear dot gene; Csprs and Ifi75 are novel genes encoding a putative G-protein coupled receptor (GPCR) and a putative transcriptional coactivator, respectively. A fourth gene, Sp100-rs, occurs in M. musculus, but not in M. caroli. Sp100-rs is a chimeric gene which arose by fusion of Sp100 and Csprs copies. Sp100-rs and Ifi75 are components of a repeat cluster that extends over 6-200 Mb of the M. musculus genome. The Sp100-rs fusion gene arose only 1-2 million years ago and has become fixed and amplified in M. musculus. Although the gene is transcribed, it appears to have no function. The repeat cluster may have become fixed in the species as a "hitchhiker" in a "selective sweep".

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DO - 10.1007/s00335-001-3015-9

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AN - SCOPUS:0034924923

SN - 0938-8990

VL - 12

SP - 590

EP - 594

JO - Mammalian Genome

JF - Mammalian Genome

IS - 8

ER -

Source and component genes of a 6-200 Mb gene cluster in the house mouse

Abstract

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