Source and component genes of a 6-200 Mb gene cluster in the house mouse

Dieter Weichenhan*, Bärbel Kunze, Heinz Winking, Michel Van Geel, Kazutoyo Osoegawa, Pieter J. De Jong, Walther Traut

*Corresponding author for this work
16 Citations (Scopus)


We identified and analyzed the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli. Sp100 is a nuclear dot gene; Csprs and Ifi75 are novel genes encoding a putative G-protein coupled receptor (GPCR) and a putative transcriptional coactivator, respectively. A fourth gene, Sp100-rs, occurs in M. musculus, but not in M. caroli. Sp100-rs is a chimeric gene which arose by fusion of Sp100 and Csprs copies. Sp100-rs and Ifi75 are components of a repeat cluster that extends over 6-200 Mb of the M. musculus genome. The Sp100-rs fusion gene arose only 1-2 million years ago and has become fixed and amplified in M. musculus. Although the gene is transcribed, it appears to have no function. The repeat cluster may have become fixed in the species as a "hitchhiker" in a "selective sweep".

Original languageEnglish
JournalMammalian Genome
Issue number8
Pages (from-to)590-594
Number of pages5
Publication statusPublished - 04.08.2001


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