Somatostatin-analoga in der therapie des fortgeschrittenen hormonrefraktären prostatakarzinoms: Eine möglichkeit der sekundären hormonablation?

Translated title of the contribution: Somatostatin analogs for the treatment of advanced, hormone-refractory prostate cancer: A possibility for secondary hormonal ablation?

D. Schilling, R. Küfer, S. Kruck, Arnulf Stenzl, M. A. Kuczyk, A. S. Merseburger

3 Citations (Scopus)

Abstract

Almost all patients with hormone-refractory prostate cancer under primary androgen deprivation therapy will develop progression, frequently initially marked by an asymptomatic increase of prostate-specific antigen (PSA). Recent data showed that taxane-based chemotherapy offers significant survival benefit to patients with advanced prostate cancer; however, the toxic side effects frequently exert a significant negative impact on the quality of life. At the androgen-independent stage of the cancer, before becoming hormone refractory, progression might still be delayed by secondary manipulation of either androgen or confounding receptors and their signaling pathways. Secondary hormonal manipulations traditionally included antiandrogen withdrawal, second-line antiandrogens, direct adrenal androgen inhibitors, estrogens, and progestins. We discuss the mode of action and application of somatostatin analogs as an emerging secondary hormonal treatment concept in patients with advanced prostate cancer on the basis of the current literature.

Translated title of the contributionSomatostatin analogs for the treatment of advanced, hormone-refractory prostate cancer: A possibility for secondary hormonal ablation?
Original languageGerman
JournalUrologe - Ausgabe A
Volume47
Issue number10
Pages (from-to)1334-1338
Number of pages5
ISSN0340-2592
DOIs
Publication statusPublished - 10.2008

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)

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