Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration

Benjamin Anderschou Holbech Jensen; Marc Heyndrickx; Daisy Jonkers; Alan Mackie; Sam Millet; Malwina Naghibi; Simone Isling Pærregaard; Bruno Pot; Delphine Saulnier; Christian Sina; Luc Gerardus Willibrordus Sterkman; Pieter Van den Abbeele; Naomi Vita Venlet; Erwin G. Zoetendal; Arthur Constantijn Ouwehand

doi:10.1016/j.xcrm.2023.101190

Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration

Benjamin Anderschou Holbech Jensen^*, Marc Heyndrickx, Daisy Jonkers, Alan Mackie, Sam Millet, Malwina Naghibi, Simone Isling Pærregaard, Bruno Pot, Delphine Saulnier, Christian Sina, Luc Gerardus Willibrordus Sterkman, Pieter Van den Abbeele, Naomi Vita Venlet^*, Erwin G. Zoetendal, Arthur Constantijn Ouwehand

^*Corresponding author for this work

Institute of Nutrition Medicine

56 Citations (Scopus)

Abstract

Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.

Original language	English
Article number	101190
Journal	Cell Reports Medicine
Volume	4
Issue number	9
DOIs	https://doi.org/10.1016/j.xcrm.2023.101190
Publication status	Published - 19.09.2023

Funding

This work was conducted by an expert group (EG) of ILSI Europe. Composition of the EG is listed on the ILSI Europe website at https://ilsi.eu/scientific-activities/nutrition/probiotics/. ILSI Europe facilitated scientific meetings and coordinated the overall project management and administrative tasks relating to the completion of this work. This manuscript was copy edited by Cath Mersh. Traveling and accommodation expenses were covered by ILSI Europe. All authors contributed to design and writing of the first manuscript draft. B.A.H.J. and A.C.O. led the process of editing and contextualizing the body text while integrating the contributions of each individual author. B.A.H.J. was responsible for the final editing of the manuscript. First and last authors are positioned according to standard guidelines. Remaining authors are ordered alphabetically, emphasizing the joint effort. A.C.O. M.N. B.P. D.S. L.G.W.S. and P.V.D.A. work full time for IFF, ADM, Yakult, Novozymes, Caelus Health, and Cryptobiotix respectively. These companies were not involved in carrying out this research.

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

2.22-05 Nutritional Sciences
2.21-01 Metabolism, Biochemistry and Genetics of Microorganisms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Jensen, B. A. H., Heyndrickx, M., Jonkers, D., Mackie, A., Millet, S., Naghibi, M., Pærregaard, S. I., Pot, B., Saulnier, D., Sina, C., Sterkman, L. G. W., Van den Abbeele, P., Venlet, N. V., Zoetendal, E. G., & Ouwehand, A. C. (2023). Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration. Cell Reports Medicine, 4(9), Article 101190. https://doi.org/10.1016/j.xcrm.2023.101190

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title = "Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration",

abstract = "Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.",

author = "Jensen, \{Benjamin Anderschou Holbech\} and Marc Heyndrickx and Daisy Jonkers and Alan Mackie and Sam Millet and Malwina Naghibi and P{\ae}rregaard, \{Simone Isling\} and Bruno Pot and Delphine Saulnier and Christian Sina and Sterkman, \{Luc Gerardus Willibrordus\} and \{Van den Abbeele\}, Pieter and Venlet, \{Naomi Vita\} and Zoetendal, \{Erwin G.\} and Ouwehand, \{Arthur Constantijn\}",

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Jensen, BAH, Heyndrickx, M, Jonkers, D, Mackie, A, Millet, S, Naghibi, M, Pærregaard, SI, Pot, B, Saulnier, D, Sina, C, Sterkman, LGW, Van den Abbeele, P, Venlet, NV, Zoetendal, EG & Ouwehand, AC 2023, 'Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration', Cell Reports Medicine, vol. 4, no. 9, 101190. https://doi.org/10.1016/j.xcrm.2023.101190

TY - JOUR

T1 - Small intestine vs. colon ecology and physiology

T2 - Why it matters in probiotic administration

AU - Jensen, Benjamin Anderschou Holbech

AU - Heyndrickx, Marc

AU - Jonkers, Daisy

AU - Mackie, Alan

AU - Millet, Sam

AU - Naghibi, Malwina

AU - Pærregaard, Simone Isling

AU - Pot, Bruno

AU - Saulnier, Delphine

AU - Sina, Christian

AU - Sterkman, Luc Gerardus Willibrordus

AU - Van den Abbeele, Pieter

AU - Venlet, Naomi Vita

AU - Zoetendal, Erwin G.

AU - Ouwehand, Arthur Constantijn

PY - 2023/9/19

Y1 - 2023/9/19

N2 - Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.

AB - Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.

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Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration

Abstract

Funding

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

Access to Document

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