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Abstract
The application of transcranial slow oscillation stimulation (tSOS; 0.75 Hz) was previously shown to enhance widespread endogenous EEG slow oscillatory activity when applied during a sleep period characterized by emerging endogenous slow oscillatory activity. Processes of memory consolidation typically occurring during this state of sleep were also enhanced. Here, we show that the same tSOS applied in the waking brain also induced an increase in endogenous EEG slow oscillations (0.4-1.2 Hz), although in a topographically restricted fashion. Applied during wakefulness tSOS, additionally, resulted in a marked and widespread increase in EEG theta (4-8 Hz) activity. During wake, tSOS did not enhance consolidation of memories when applied after learning, but improved encoding of hippocampus-dependent memories when applied during learning. We conclude that the EEG frequency and related memory processes induced by tSOS critically depend on brain state. In response to tSOS during wakefulness the brain transposes stimulation by responding preferentially with theta oscillations and facilitated encoding.
Original language | English |
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Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 106 |
Issue number | 36 |
Pages (from-to) | 15460-15465 |
Number of pages | 6 |
ISSN | 0027-8424 |
DOIs | |
Publication status | Published - 08.09.2009 |
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Dive into the research topics of 'Slow oscillation electrical brain stimulation during waking promotes EEG theta activity and memory encoding'. Together they form a unique fingerprint.Projects
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Graduate School GSC 235: Graduate School for Computing in Medicine and Life Sciences
Schweikard, A., Anders, S., Barkhausen, J., Buzug, T., Erdmann, J., Fischer, B., Fischer, S., Habermann, J. K., Hartmann, E., Hilgenfeld, R., Hofmann, U., Klein, C., Kruse, C., Marshall, L., Martinetz, T., Mertins, A., Münte, T., Oltmanns, K., Schneider, S., Schunkert, H., Sczakiel, G., Tronnier, V. M., Vogel, A., Westermann, J. & Zillikens, D.
01.11.07 → 31.12.14
Project: DFG Projects › DFG Joint Research: Research Training Groups