TY - JOUR
T1 - Sleep promotes T-cell migration towards CCL19 via growth hormone and prolactin signaling in humans
AU - Martínez-Albert, Estefanía
AU - Lutz, Nicolas D
AU - Hübener, Robert
AU - Dimitrov, Stoyan
AU - Lange, Tanja
AU - Born, Jan
AU - Besedovsky, Luciana
N1 - Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
Publisher Copyright:
© 2024 The Authors
PY - 2024/2
Y1 - 2024/2
N2 - Sleep strongly supports the formation of adaptive immunity, e.g., after vaccination. However, the underlying mechanisms remain largely obscure. Here we show in healthy humans that sleep compared to nocturnal wakefulness specifically promotes the migration of various T-cell subsets towards the chemokine CCL19, which is essential for lymph-node homing and, thus, for the initiation and maintenance of adaptive immune responses. Migration towards the inflammatory chemokine CCL5 remained unaffected. Incubating the cells with plasma from sleeping participants likewise increased CCL19-directed migration, an effect that was dependent on growth hormone and prolactin signaling. These findings show that sleep selectively promotes the lymph node homing potential of T cells by increasing hormonal release, and thus reveal a causal mechanism underlying the supporting effect of sleep on adaptive immunity in humans.
AB - Sleep strongly supports the formation of adaptive immunity, e.g., after vaccination. However, the underlying mechanisms remain largely obscure. Here we show in healthy humans that sleep compared to nocturnal wakefulness specifically promotes the migration of various T-cell subsets towards the chemokine CCL19, which is essential for lymph-node homing and, thus, for the initiation and maintenance of adaptive immune responses. Migration towards the inflammatory chemokine CCL5 remained unaffected. Incubating the cells with plasma from sleeping participants likewise increased CCL19-directed migration, an effect that was dependent on growth hormone and prolactin signaling. These findings show that sleep selectively promotes the lymph node homing potential of T cells by increasing hormonal release, and thus reveal a causal mechanism underlying the supporting effect of sleep on adaptive immunity in humans.
UR - https://www.mendeley.com/catalogue/0158b994-7f69-30f0-9258-d3c6bfd3456f/
UR - http://www.scopus.com/inward/record.url?scp=85186751819&partnerID=8YFLogxK
U2 - 10.1016/j.bbi.2024.02.021
DO - 10.1016/j.bbi.2024.02.021
M3 - Journal articles
C2 - 38369248
SN - 0889-1591
VL - 118
SP - 69
EP - 77
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
ER -