Sleep Matters: CD4+ T Cell Memory Formation and the Central Nervous System

Tanja Lange; Jan Born; Jürgen Westermann

doi:10.1016/j.it.2019.06.003

Sleep Matters: CD4+ T Cell Memory Formation and the Central Nervous System

Tanja Lange, Jan Born, Jürgen Westermann^*

^*Corresponding author for this work

13 Citations (Scopus)

Abstract

The mechanisms of CD4⁺ T-cell memory formation in the immune system are debated. With the well-established concept of memory formation in the central nervous system (CNS), we propose that formation of CD4⁺ T-cell memory depends on the interaction of two different cell systems handling two types of stored information. First, information about antigen (event) and challenge (context) is taken up by antigen-presenting cells, as initial storage. Second, event and context information is transferred to CD4⁺ T cells. During activation, two categories of CD4⁺ T cell develop: effector CD4⁺ T cells, carrying event and context information, enabling them to efficiently focus their response to tissues under attack; and persisting CD4⁺ T cells, providing context-independent antigen-specific memories and long-term storage. This novel hypothesis is supported by the observation that mammalian sleep can improve both CNS and CD4⁺ T-cell memory.

Original language	English
Journal	Trends in Immunology
Volume	40
Issue number	8
Pages (from-to)	674-686
Number of pages	13
ISSN	1471-4906
DOIs	https://doi.org/10.1016/j.it.2019.06.003
Publication status	Published - 08.2019

Funding

We thank Marc Jenkins, Peter König, Tamas Laskay, Andrea Schampel, Werner Solbach, Johannes Textor, and the members of our laboratories for valuable comments. This work was supported by grants from the Deutsche Forschungsgemeinschaft ( TR-SFB 654 ‘Plasticity and Sleep’).

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)
Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.it.2019.06.003

Cite this

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title = "Sleep Matters: CD4+ T Cell Memory Formation and the Central Nervous System",

abstract = "The mechanisms of CD4+ T-cell memory formation in the immune system are debated. With the well-established concept of memory formation in the central nervous system (CNS), we propose that formation of CD4+ T-cell memory depends on the interaction of two different cell systems handling two types of stored information. First, information about antigen (event) and challenge (context) is taken up by antigen-presenting cells, as initial storage. Second, event and context information is transferred to CD4+ T cells. During activation, two categories of CD4+ T cell develop: effector CD4+ T cells, carrying event and context information, enabling them to efficiently focus their response to tissues under attack; and persisting CD4+ T cells, providing context-independent antigen-specific memories and long-term storage. This novel hypothesis is supported by the observation that mammalian sleep can improve both CNS and CD4+ T-cell memory.",

author = "Tanja Lange and Jan Born and J{\"u}rgen Westermann",

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AU - Lange, Tanja

AU - Born, Jan

AU - Westermann, Jürgen

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N2 - The mechanisms of CD4+ T-cell memory formation in the immune system are debated. With the well-established concept of memory formation in the central nervous system (CNS), we propose that formation of CD4+ T-cell memory depends on the interaction of two different cell systems handling two types of stored information. First, information about antigen (event) and challenge (context) is taken up by antigen-presenting cells, as initial storage. Second, event and context information is transferred to CD4+ T cells. During activation, two categories of CD4+ T cell develop: effector CD4+ T cells, carrying event and context information, enabling them to efficiently focus their response to tissues under attack; and persisting CD4+ T cells, providing context-independent antigen-specific memories and long-term storage. This novel hypothesis is supported by the observation that mammalian sleep can improve both CNS and CD4+ T-cell memory.

AB - The mechanisms of CD4+ T-cell memory formation in the immune system are debated. With the well-established concept of memory formation in the central nervous system (CNS), we propose that formation of CD4+ T-cell memory depends on the interaction of two different cell systems handling two types of stored information. First, information about antigen (event) and challenge (context) is taken up by antigen-presenting cells, as initial storage. Second, event and context information is transferred to CD4+ T cells. During activation, two categories of CD4+ T cell develop: effector CD4+ T cells, carrying event and context information, enabling them to efficiently focus their response to tissues under attack; and persisting CD4+ T cells, providing context-independent antigen-specific memories and long-term storage. This novel hypothesis is supported by the observation that mammalian sleep can improve both CNS and CD4+ T-cell memory.

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Sleep Matters: CD4+ T Cell Memory Formation and the Central Nervous System

Abstract

Funding

Research Areas and Centers

UN SDGs

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