Sleep deprivation induces fragmented memory loss

Jennifer E. Ashton; Marcus O. Harrington; Diane Langthorne; Hong Viet V. Ngo; Scott A. Cairney

doi:10.1101/lm.050757.119

Sleep deprivation induces fragmented memory loss

Jennifer E. Ashton, Marcus O. Harrington, Diane Langthorne, Hong Viet V. Ngo, Scott A. Cairney^*

^*Corresponding author for this work

Institute of Experimental and Clinical Pharmacology and Toxicology

University of York

31 Citations (Scopus)

Abstract

Sleep deprivation increases rates of forgetting in episodic memory. Yet, whether an extended lack of sleep alters the qualitative nature of forgetting is unknown. We compared forgetting of episodic memories across intervals of overnight sleep, daytime wakefulness, and overnight sleep deprivation. Item-level forgetting was amplified across daytime wakefulness and overnight sleep deprivation, as compared to sleep. Importantly, however, overnight sleep deprivation led to a further deficit in associative memory that was not observed after daytime wakefulness. These findings suggest that sleep deprivation induces fragmentation among item memories and their associations, altering the qualitative nature of episodic forgetting.

Original language	English
Journal	Learning and Memory
Volume	27
Issue number	4
Pages (from-to)	130-135
Number of pages	6
ISSN	1072-0502
DOIs	https://doi.org/10.1101/lm.050757.119
Publication status	Published - 04.2020

Funding

This work was supported by Medical Research Council (MRC) Career Development Award (MR/P020208/1) to S.A.C. We are very grateful to two anonymous reviewers for their helpful comments on an earlier version of this manuscript.

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1101/lm.050757.119

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title = "Sleep deprivation induces fragmented memory loss",

abstract = "Sleep deprivation increases rates of forgetting in episodic memory. Yet, whether an extended lack of sleep alters the qualitative nature of forgetting is unknown. We compared forgetting of episodic memories across intervals of overnight sleep, daytime wakefulness, and overnight sleep deprivation. Item-level forgetting was amplified across daytime wakefulness and overnight sleep deprivation, as compared to sleep. Importantly, however, overnight sleep deprivation led to a further deficit in associative memory that was not observed after daytime wakefulness. These findings suggest that sleep deprivation induces fragmentation among item memories and their associations, altering the qualitative nature of episodic forgetting.",

author = "Ashton, \{Jennifer E.\} and Harrington, \{Marcus O.\} and Diane Langthorne and Ngo, \{Hong Viet V.\} and Cairney, \{Scott A.\}",

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year = "2020",

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doi = "10.1101/lm.050757.119",

language = "English",

volume = "27",

pages = "130--135",

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AU - Ashton, Jennifer E.

AU - Harrington, Marcus O.

AU - Langthorne, Diane

AU - Ngo, Hong Viet V.

AU - Cairney, Scott A.

N1 - Funding Information: This work was supported by Medical Research Council (MRC) Career Development Award (MR/P020208/1) to S.A.C. We are very grateful to two anonymous reviewers for their helpful comments on an earlier version of this manuscript. Publisher Copyright: © 2020 Ashton et al. This article, published in Learning & Memory, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/4

Y1 - 2020/4

N2 - Sleep deprivation increases rates of forgetting in episodic memory. Yet, whether an extended lack of sleep alters the qualitative nature of forgetting is unknown. We compared forgetting of episodic memories across intervals of overnight sleep, daytime wakefulness, and overnight sleep deprivation. Item-level forgetting was amplified across daytime wakefulness and overnight sleep deprivation, as compared to sleep. Importantly, however, overnight sleep deprivation led to a further deficit in associative memory that was not observed after daytime wakefulness. These findings suggest that sleep deprivation induces fragmentation among item memories and their associations, altering the qualitative nature of episodic forgetting.

AB - Sleep deprivation increases rates of forgetting in episodic memory. Yet, whether an extended lack of sleep alters the qualitative nature of forgetting is unknown. We compared forgetting of episodic memories across intervals of overnight sleep, daytime wakefulness, and overnight sleep deprivation. Item-level forgetting was amplified across daytime wakefulness and overnight sleep deprivation, as compared to sleep. Importantly, however, overnight sleep deprivation led to a further deficit in associative memory that was not observed after daytime wakefulness. These findings suggest that sleep deprivation induces fragmentation among item memories and their associations, altering the qualitative nature of episodic forgetting.

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Sleep deprivation induces fragmented memory loss

Abstract

Funding

Research Areas and Centers

UN SDGs

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