Skin melanoma deaths within 1 or 3 years from diagnosis in Europe

Lidia Sacchetto; Stefano Rosso; Harry Comber; Christine Bouchardy; Paolo Broganelli; Jaume Galceran; Monika Hackl; Alexander Katalinic; Marieke Louwman; Trude E. Robsahm; Laufey Tryggvadottir; Rosario Tumino; Elizabeth Van Eycken; Paul M. Walsh; Vesna Zadnik; Roberto Zanetti

doi:10.1002/ijc.33479

Skin melanoma deaths within 1 or 3 years from diagnosis in Europe

Lidia Sacchetto^*, Stefano Rosso, Harry Comber, Christine Bouchardy, Paolo Broganelli, Jaume Galceran, Monika Hackl, Alexander Katalinic, Marieke Louwman, Trude E. Robsahm, Laufey Tryggvadottir, Rosario Tumino, Elizabeth Van Eycken, Paul M. Walsh, Vesna Zadnik, Roberto Zanetti

^*Corresponding author for this work

18 Citations (Scopus)

Abstract

The steep increase in incidence of cutaneous malignant melanoma in white populations mainly applies to thin lesions with good survival suggesting overdiagnosis. Based on population-based cancer registries (CRs), we have investigated changes in aggressive melanoma, selecting only cases who died within 1 or 3 years after diagnosis in 11 European countries between 1995 and 2012. Trends in fatal cases were analysed by period of diagnosis, sex, tumour thickness, histologic subtype of the lesion, tumour site and CR with a multivariate generalised linear mixed effects model, where geographical area was considered as a random effect. We collected data on 123 360 invasive melanomas, with 5133 fatal cases at 1 year (4%) and 12 330 (10%) at 3 years. The number of fatal cases showed a 16% decrease at 1 year and 8% at 3 years between the first (1995-2000) and the last (2007-2012) period. The highest proportion of fatal cases was seen for men, older age (≥65 years), thick lesions (>1 mm), nodular melanoma, melanoma on the trunk and for poorly documented cases, lacking information about thickness and histologic subtype. The mixed-effects model showed a remarkable variability among European countries. The majority of registries showed a decreasing trend in fatal cases, but a few registries showed an opposite pattern. Trends in fatal melanoma cases, highlighting real changes in risk not related to overdiagnosis, showed a decrease in most European countries, with a few exceptions. Stronger efforts for early detection could lead to a more efficient treatment of melanoma in general.

Original language	English
Journal	International Journal of Cancer
Volume	148
Issue number	12
Pages (from-to)	2898-2905
Number of pages	8
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.33479
Publication status	Published - 15.06.2021

Funding

The authors would like to thank the Trends in Melanoma Working Group (TIM WG) members for contributing to this study with their data. Trends in Melanoma Working Group (TIM WG): Austrian CR: Monika Hackl, Henrike Karim-Kos; Belgium CR: Elizabeth Van Eycken; Schleswig-Holstein Registry (Germany): Alexander Katalinic, Miriam Holzmann; Iceland CR: Laufey Tryggvad?ttir, El?nborg ?lafsd?ttir; Ireland CR: Harry Comber, Conan Donnelly; Piedmont CR (Italy): Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Paolo Broganelli; Ragusa CR (Italy): Rosario Tumino, Graziella Frasca; Norwegian CR: Trude Eid Robsahm, Siri Lar?nningen; Cluj Regional CR (Romania): Dana Coza, Ofelia Suteu; Slovenia CR: Vesna Zadnik, Maja Primic-Zakelj; Granada CR (Spain): Maria Jose? Sanchez P?rez, Miguel Rodriguez-Barranco; Murcia CR (Spain): Carmen Navarro S?nchez, Diego Salmer?n Mart?nez, Mar?a-Dolores Chirlaque; Tarragona CR (Spain): Jaume Galceran, Mari? Carulla; Geneva CR (Switzerland): Christine Bouchardy, Elisabetta Rapiti, Robin Schaffar, Massimo Usel; Netherlands CR: Marieke Louwman; Eindhoven CR (Netherlands): Jan Willem Coebergh; National Cancer Intelligence Network, England (UK): Sally Vernon, Sean McPhail, Veronique Poirier; Northern Ireland CR (UK): Anna Gavin, Eileen Morgan; Scottish CR: David H. Brewster, Lesley A. Bhatti, Andy Deas.

Research Areas and Centers

Research Area: Center for Population Medicine and Public Health (ZBV)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Sacchetto, L., Rosso, S., Comber, H., Bouchardy, C., Broganelli, P., Galceran, J., Hackl, M., Katalinic, A., Louwman, M., Robsahm, T. E., Tryggvadottir, L., Tumino, R., Van Eycken, E., Walsh, P. M., Zadnik, V., & Zanetti, R. (2021). Skin melanoma deaths within 1 or 3 years from diagnosis in Europe. International Journal of Cancer, 148(12), 2898-2905. https://doi.org/10.1002/ijc.33479

@article{f4f228fe13e64bddae261a0d220efc7a,

title = "Skin melanoma deaths within 1 or 3 years from diagnosis in Europe",

abstract = "The steep increase in incidence of cutaneous malignant melanoma in white populations mainly applies to thin lesions with good survival suggesting overdiagnosis. Based on population-based cancer registries (CRs), we have investigated changes in aggressive melanoma, selecting only cases who died within 1 or 3 years after diagnosis in 11 European countries between 1995 and 2012. Trends in fatal cases were analysed by period of diagnosis, sex, tumour thickness, histologic subtype of the lesion, tumour site and CR with a multivariate generalised linear mixed effects model, where geographical area was considered as a random effect. We collected data on 123 360 invasive melanomas, with 5133 fatal cases at 1 year (4\%) and 12 330 (10\%) at 3 years. The number of fatal cases showed a 16\% decrease at 1 year and 8\% at 3 years between the first (1995-2000) and the last (2007-2012) period. The highest proportion of fatal cases was seen for men, older age (≥65 years), thick lesions (>1 mm), nodular melanoma, melanoma on the trunk and for poorly documented cases, lacking information about thickness and histologic subtype. The mixed-effects model showed a remarkable variability among European countries. The majority of registries showed a decreasing trend in fatal cases, but a few registries showed an opposite pattern. Trends in fatal melanoma cases, highlighting real changes in risk not related to overdiagnosis, showed a decrease in most European countries, with a few exceptions. Stronger efforts for early detection could lead to a more efficient treatment of melanoma in general.",

author = "Lidia Sacchetto and Stefano Rosso and Harry Comber and Christine Bouchardy and Paolo Broganelli and Jaume Galceran and Monika Hackl and Alexander Katalinic and Marieke Louwman and Robsahm, \{Trude E.\} and Laufey Tryggvadottir and Rosario Tumino and \{Van Eycken\}, Elizabeth and Walsh, \{Paul M.\} and Vesna Zadnik and Roberto Zanetti",

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Sacchetto, L, Rosso, S, Comber, H, Bouchardy, C, Broganelli, P, Galceran, J, Hackl, M, Katalinic, A, Louwman, M, Robsahm, TE, Tryggvadottir, L, Tumino, R, Van Eycken, E, Walsh, PM, Zadnik, V & Zanetti, R 2021, 'Skin melanoma deaths within 1 or 3 years from diagnosis in Europe', International Journal of Cancer, vol. 148, no. 12, pp. 2898-2905. https://doi.org/10.1002/ijc.33479

TY - JOUR

T1 - Skin melanoma deaths within 1 or 3 years from diagnosis in Europe

AU - Sacchetto, Lidia

AU - Rosso, Stefano

AU - Comber, Harry

AU - Bouchardy, Christine

AU - Broganelli, Paolo

AU - Galceran, Jaume

AU - Hackl, Monika

AU - Katalinic, Alexander

AU - Louwman, Marieke

AU - Robsahm, Trude E.

AU - Tryggvadottir, Laufey

AU - Tumino, Rosario

AU - Van Eycken, Elizabeth

AU - Walsh, Paul M.

AU - Zadnik, Vesna

AU - Zanetti, Roberto

PY - 2021/6/15

Y1 - 2021/6/15

N2 - The steep increase in incidence of cutaneous malignant melanoma in white populations mainly applies to thin lesions with good survival suggesting overdiagnosis. Based on population-based cancer registries (CRs), we have investigated changes in aggressive melanoma, selecting only cases who died within 1 or 3 years after diagnosis in 11 European countries between 1995 and 2012. Trends in fatal cases were analysed by period of diagnosis, sex, tumour thickness, histologic subtype of the lesion, tumour site and CR with a multivariate generalised linear mixed effects model, where geographical area was considered as a random effect. We collected data on 123 360 invasive melanomas, with 5133 fatal cases at 1 year (4%) and 12 330 (10%) at 3 years. The number of fatal cases showed a 16% decrease at 1 year and 8% at 3 years between the first (1995-2000) and the last (2007-2012) period. The highest proportion of fatal cases was seen for men, older age (≥65 years), thick lesions (>1 mm), nodular melanoma, melanoma on the trunk and for poorly documented cases, lacking information about thickness and histologic subtype. The mixed-effects model showed a remarkable variability among European countries. The majority of registries showed a decreasing trend in fatal cases, but a few registries showed an opposite pattern. Trends in fatal melanoma cases, highlighting real changes in risk not related to overdiagnosis, showed a decrease in most European countries, with a few exceptions. Stronger efforts for early detection could lead to a more efficient treatment of melanoma in general.

AB - The steep increase in incidence of cutaneous malignant melanoma in white populations mainly applies to thin lesions with good survival suggesting overdiagnosis. Based on population-based cancer registries (CRs), we have investigated changes in aggressive melanoma, selecting only cases who died within 1 or 3 years after diagnosis in 11 European countries between 1995 and 2012. Trends in fatal cases were analysed by period of diagnosis, sex, tumour thickness, histologic subtype of the lesion, tumour site and CR with a multivariate generalised linear mixed effects model, where geographical area was considered as a random effect. We collected data on 123 360 invasive melanomas, with 5133 fatal cases at 1 year (4%) and 12 330 (10%) at 3 years. The number of fatal cases showed a 16% decrease at 1 year and 8% at 3 years between the first (1995-2000) and the last (2007-2012) period. The highest proportion of fatal cases was seen for men, older age (≥65 years), thick lesions (>1 mm), nodular melanoma, melanoma on the trunk and for poorly documented cases, lacking information about thickness and histologic subtype. The mixed-effects model showed a remarkable variability among European countries. The majority of registries showed a decreasing trend in fatal cases, but a few registries showed an opposite pattern. Trends in fatal melanoma cases, highlighting real changes in risk not related to overdiagnosis, showed a decrease in most European countries, with a few exceptions. Stronger efforts for early detection could lead to a more efficient treatment of melanoma in general.

UR - https://www.scopus.com/pages/publications/85100027276

U2 - 10.1002/ijc.33479

DO - 10.1002/ijc.33479

M3 - Journal articles

C2 - 33497469

AN - SCOPUS:85100027276

SN - 0020-7136

VL - 148

SP - 2898

EP - 2905

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 12

ER -

Skin melanoma deaths within 1 or 3 years from diagnosis in Europe

Abstract

Funding

Research Areas and Centers

UN SDGs

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