Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells

Jennifer Kajahn; Erwin Gorjup; Stephan Tiede; Hagen von Briesen; Ralf Paus; Charli Kruse; Sandra Danner

doi:10.1016/j.ejcb.2007.07.004

Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells

Jennifer Kajahn, Erwin Gorjup, Stephan Tiede, Hagen von Briesen, Ralf Paus, Charli Kruse, Sandra Danner^*

^*Corresponding author for this work

34 Citations (Scopus)

Abstract

Multiple tissue niches in the human body are now recognised to harbour stem cells. Here, we have asked how different adult stem cell populations, isolated from two ontogenetically distinct human organs (skin, pancreas), actually are with respect to a panel of standard markers/characteristics. Here we show that an easily accessible adult human tissue such as skin may serve as a convenient source of adult stem cell-like populations that share markers with stem cells derived from an internal, exocrine organ. Surprisingly, both, human pancreas- and skin-derived stem/progenitor cells demonstrate differentiation patterns across lineage boundaries into cell types of ectoderm (e.g. PGP 9.5+ and GFAP+), mesoderm (e.g. α-SMA+) and entoderm (e.g. amylase+ and albumin+). This intriguing differentiation capability warrants systemic follow-up, since it raises the theoretical possibility that an adult human skin-derived progenitor cell population could be envisioned for possible application in cell replacement therapies.

Original language	English
Journal	European Journal of Cell Biology
Volume	87
Issue number	1
Pages (from-to)	39-46
Number of pages	8
ISSN	0171-9335
DOIs	https://doi.org/10.1016/j.ejcb.2007.07.004
Publication status	Published - 15.01.2008

Funding

The authors would like to thank Emel Klink, Enikö Bodo and Sascha Wien for excellent help regarding cell isolation, cultivation and characterisation. This work was supported in part by grants from the European Union (CellPROM) and the Faculty Research Focus on Regenerative Medicine (R. Paus and C. Kruse), University of Luebeck.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.ejcb.2007.07.004

Cite this

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title = "Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells",

abstract = "Multiple tissue niches in the human body are now recognised to harbour stem cells. Here, we have asked how different adult stem cell populations, isolated from two ontogenetically distinct human organs (skin, pancreas), actually are with respect to a panel of standard markers/characteristics. Here we show that an easily accessible adult human tissue such as skin may serve as a convenient source of adult stem cell-like populations that share markers with stem cells derived from an internal, exocrine organ. Surprisingly, both, human pancreas- and skin-derived stem/progenitor cells demonstrate differentiation patterns across lineage boundaries into cell types of ectoderm (e.g. PGP 9.5+ and GFAP+), mesoderm (e.g. α-SMA+) and entoderm (e.g. amylase+ and albumin+). This intriguing differentiation capability warrants systemic follow-up, since it raises the theoretical possibility that an adult human skin-derived progenitor cell population could be envisioned for possible application in cell replacement therapies.",

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AU - Kajahn, Jennifer

AU - Gorjup, Erwin

AU - Tiede, Stephan

AU - von Briesen, Hagen

AU - Paus, Ralf

AU - Kruse, Charli

AU - Danner, Sandra

PY - 2008/1/15

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N2 - Multiple tissue niches in the human body are now recognised to harbour stem cells. Here, we have asked how different adult stem cell populations, isolated from two ontogenetically distinct human organs (skin, pancreas), actually are with respect to a panel of standard markers/characteristics. Here we show that an easily accessible adult human tissue such as skin may serve as a convenient source of adult stem cell-like populations that share markers with stem cells derived from an internal, exocrine organ. Surprisingly, both, human pancreas- and skin-derived stem/progenitor cells demonstrate differentiation patterns across lineage boundaries into cell types of ectoderm (e.g. PGP 9.5+ and GFAP+), mesoderm (e.g. α-SMA+) and entoderm (e.g. amylase+ and albumin+). This intriguing differentiation capability warrants systemic follow-up, since it raises the theoretical possibility that an adult human skin-derived progenitor cell population could be envisioned for possible application in cell replacement therapies.

AB - Multiple tissue niches in the human body are now recognised to harbour stem cells. Here, we have asked how different adult stem cell populations, isolated from two ontogenetically distinct human organs (skin, pancreas), actually are with respect to a panel of standard markers/characteristics. Here we show that an easily accessible adult human tissue such as skin may serve as a convenient source of adult stem cell-like populations that share markers with stem cells derived from an internal, exocrine organ. Surprisingly, both, human pancreas- and skin-derived stem/progenitor cells demonstrate differentiation patterns across lineage boundaries into cell types of ectoderm (e.g. PGP 9.5+ and GFAP+), mesoderm (e.g. α-SMA+) and entoderm (e.g. amylase+ and albumin+). This intriguing differentiation capability warrants systemic follow-up, since it raises the theoretical possibility that an adult human skin-derived progenitor cell population could be envisioned for possible application in cell replacement therapies.

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Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells

Abstract

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