Skin cleansers: Three test protocols for the assessment of irritancy ranking

Julia Spoo*, Walter Wigger-Alberti, Undine Berndt, Tobias Fischer, Peter Elsner

*Corresponding author for this work
29 Citations (Scopus)


In this article, the results of 3 studies on 2 hand cleansers (products A and B) are analysed. Three different test models (the patch test, the forearm wash test and the use test) are used to obtain information on the skin irritancy of these 2 products. Test reactivity was assessed by clinical scores and bioengineering methods such as corneometry for skin moisture, transepidermal water loss measurements for barrier function and chromametry for erythema. A correlating trend of product A being more aggressive than product B could be confirmed in all 3 studies and was statistically significant in the patch-testing series. Distinction of the results was dependent on the test protocol employed. Models for testing cleansing preparations should be chosen carefully, depending on the hypothesis to be evaluated.

Original languageEnglish
JournalActa Dermato-Venereologica
Issue number1
Pages (from-to)13-17
Number of pages5
Publication statusPublished - 2002


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