Skin barrier integrity and natural moisturising factor levels after cumulative dermal exposure to alkaline agents in atopic dermatitis

Irena Angelova-Fischer*, Irena Dapic, Anne Karin Hoek, Ivone Jakasa, Tobias W. Fischer, Detlef Zillikens, Sanja Kezic

*Corresponding author for this work
22 Citations (Scopus)

Abstract

Dermal exposure to alkaline agents may lead to skin barrier damage and irritant contact dermatitis. The objective of this study was to investigate the effects of cumulative exposure to 0.5% sodium lauryl sulphate (SLS) and 0.15% NaOH on the barrier function and natural moisturising factor (NMF) levels in atopic dermatitis and healthy volunteers with known filaggrin genotype. The skin response was monitored by measurement of erythema and transepidermal water loss. The stratum corneum NMF levels were determined by high-performance liquid chromatography. Repeated exposure to 0.5% SLS and/or 0.15% NaOH in atopic dermatitis resulted in more severe impairment of the skin barrier function. Cumulative exposure to the irritants reduced significantly NMF in both the atopic and healthy controls group. The pronounced decrease of NMF after repeated single and sequential irritant exposure may be a pathogenetically relevant factor for development of chronic irritant contact dermatitis in both healthy and atopic individuals.

Original languageEnglish
JournalActa Dermato-Venereologica
Volume94
Issue number6
Pages (from-to)640-644
Number of pages5
ISSN0001-5555
DOIs
Publication statusPublished - 01.01.2014

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