Skin barrier integrity and natural moisturising factor levels after cumulative dermal exposure to alkaline agents in atopic dermatitis

Irena Angelova-Fischer*, Irena Dapic, Anne Karin Hoek, Ivone Jakasa, Tobias W. Fischer, Detlef Zillikens, Sanja Kezic

*Corresponding author for this work
    22 Citations (Scopus)

    Abstract

    Dermal exposure to alkaline agents may lead to skin barrier damage and irritant contact dermatitis. The objective of this study was to investigate the effects of cumulative exposure to 0.5% sodium lauryl sulphate (SLS) and 0.15% NaOH on the barrier function and natural moisturising factor (NMF) levels in atopic dermatitis and healthy volunteers with known filaggrin genotype. The skin response was monitored by measurement of erythema and transepidermal water loss. The stratum corneum NMF levels were determined by high-performance liquid chromatography. Repeated exposure to 0.5% SLS and/or 0.15% NaOH in atopic dermatitis resulted in more severe impairment of the skin barrier function. Cumulative exposure to the irritants reduced significantly NMF in both the atopic and healthy controls group. The pronounced decrease of NMF after repeated single and sequential irritant exposure may be a pathogenetically relevant factor for development of chronic irritant contact dermatitis in both healthy and atopic individuals.

    Original languageEnglish
    JournalActa Dermato-Venereologica
    Volume94
    Issue number6
    Pages (from-to)640-644
    Number of pages5
    ISSN0001-5555
    DOIs
    Publication statusPublished - 01.01.2014

    Fingerprint

    Dive into the research topics of 'Skin barrier integrity and natural moisturising factor levels after cumulative dermal exposure to alkaline agents in atopic dermatitis'. Together they form a unique fingerprint.

    Cite this