TY - JOUR
T1 - Single-pulse subthalamic deep brain stimulation reduces premotor-motor facilitation in Parkinson's disease
AU - Weissbach, Anne
AU - Udupa, Kaviraja
AU - Ni, Zhen
AU - Gunraj, Carolyn
AU - Rinchon, Cricia
AU - Baarbe, Julianne
AU - Fasano, Alfonso
AU - Munhoz, Renato P.
AU - Lang, Anthony
AU - Tadic, Vera
AU - Brüggemann, Norbert
AU - Münchau, Alexander
AU - Bäumer, Tobias
AU - Chen, Robert
PY - 2019/8/7
Y1 - 2019/8/7
N2 - Introduction: Deep brain stimulation improves motor symptoms in Parkinson's disease and changes primary motor cortex excitability, but how subthalamic nucleus stimulation affects premotor-motor cortical connectivity remains unclear. Methods: We investigated 10 Parkinson patients in whom single subthalamic nucleus stimulation was time-locked to transcranial magnetic dual-coil, paired-pulse stimulation of the dorsal premotor and primary motor cortex. Premotor-motor interaction with deep brain stimulation switched off was compared to 10 controls. Results: Parkinson patients showed abnormally facilitated premotor-motor interaction with deep brain stimulation switched off compared to controls. This abnormal premotor-motor facilitation was abolished during subthalamic nucleus stimulation at 3 Hz. Conclusions: In Parkinson's disease, aberrant signals from the basal ganglia leading to a loss of physiological premotor-motor inhibition can be normalized by subthalamic deep brain stimulation. This effect is likely mediated by activation of subthalamic-pallidal-thalamic projection to the premotor cortex.
AB - Introduction: Deep brain stimulation improves motor symptoms in Parkinson's disease and changes primary motor cortex excitability, but how subthalamic nucleus stimulation affects premotor-motor cortical connectivity remains unclear. Methods: We investigated 10 Parkinson patients in whom single subthalamic nucleus stimulation was time-locked to transcranial magnetic dual-coil, paired-pulse stimulation of the dorsal premotor and primary motor cortex. Premotor-motor interaction with deep brain stimulation switched off was compared to 10 controls. Results: Parkinson patients showed abnormally facilitated premotor-motor interaction with deep brain stimulation switched off compared to controls. This abnormal premotor-motor facilitation was abolished during subthalamic nucleus stimulation at 3 Hz. Conclusions: In Parkinson's disease, aberrant signals from the basal ganglia leading to a loss of physiological premotor-motor inhibition can be normalized by subthalamic deep brain stimulation. This effect is likely mediated by activation of subthalamic-pallidal-thalamic projection to the premotor cortex.
UR - http://www.scopus.com/inward/record.url?scp=85070689484&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/singlepulse-subthalamic-deep-brain-stimulation-reduces-premotormotor-facilitation-parkinsons-disease
U2 - 10.1016/j.parkreldis.2019.08.003
DO - 10.1016/j.parkreldis.2019.08.003
M3 - Journal articles
AN - SCOPUS:85070689484
SN - 1353-8020
VL - 66
SP - 224
EP - 227
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
ER -
