Single-drop optimization of protein crystallization

Arne Meyer; Karsten Dierks; Dierk Hilterhaus; Thomas Klupsch; Peter Mühlig; Jens Kleesiek; Robert Schöpflin; Howard Einspahr; Rolf Hilgenfeld; Christian Betzel

doi:10.1107/S1744309112024074

Single-drop optimization of protein crystallization

Arne Meyer, Karsten Dierks, Dierk Hilterhaus, Thomas Klupsch, Peter Mühlig, Jens Kleesiek, Robert Schöpflin, Howard Einspahr, Rolf Hilgenfeld, Christian Betzel^*

^*Corresponding author for this work

Institute of Biochemistry

16 Citations (Scopus)

Abstract

A completely new crystal-growth device has been developed that permits charting a course across the phase diagram to produce crystalline samples optimized for diffraction experiments. The utility of the device is demonstrated for the production of crystals for the traditional X-ray diffraction data-collection experiment, of microcrystals optimal for data-collection experiments at a modern microbeam insertion-device synchrotron beamline and of nanocrystals required for data collection on an X-ray laser beamline.

Original language	English
Journal	Acta Crystallographica Section F: Structural Biology and Crystallization Communications
Volume	68
Issue number	8
Pages (from-to)	994-998
Number of pages	5
DOIs	https://doi.org/10.1107/S1744309112024074
Publication status	Published - 01.08.2012

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10.1107/S1744309112024074

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AU - Dierks, Karsten

AU - Hilterhaus, Dierk

AU - Klupsch, Thomas

AU - Mühlig, Peter

AU - Kleesiek, Jens

AU - Schöpflin, Robert

AU - Einspahr, Howard

AU - Hilgenfeld, Rolf

AU - Betzel, Christian

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Single-drop optimization of protein crystallization

Abstract

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