Single-drop optimization of protein crystallization

Arne Meyer; Karsten Dierks; Dierk Hilterhaus; Thomas Klupsch; Peter Mühlig; Jens Kleesiek; Robert Schöpflin; Howard Einspahr; Rolf Hilgenfeld; Christian Betzel

doi:10.1107/S1744309112024074

Single-drop optimization of protein crystallization

Arne Meyer, Karsten Dierks, Dierk Hilterhaus, Thomas Klupsch, Peter Mühlig, Jens Kleesiek, Robert Schöpflin, Howard Einspahr, Rolf Hilgenfeld, Christian Betzel^*

^*Corresponding author for this work

Institute of Biochemistry

16 Citations (Scopus)

Abstract

A completely new crystal-growth device has been developed that permits charting a course across the phase diagram to produce crystalline samples optimized for diffraction experiments. The utility of the device is demonstrated for the production of crystals for the traditional X-ray diffraction data-collection experiment, of microcrystals optimal for data-collection experiments at a modern microbeam insertion-device synchrotron beamline and of nanocrystals required for data collection on an X-ray laser beamline.

Original language	English
Journal	Acta Crystallographica Section F: Structural Biology and Crystallization Communications
Volume	68
Issue number	8
Pages (from-to)	994-998
Number of pages	5
DOIs	https://doi.org/10.1107/S1744309112024074
Publication status	Published - 01.08.2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1107/S1744309112024074

Cite this

@article{81a596f7f31646fbb039a602b236607f,

title = "Single-drop optimization of protein crystallization",

abstract = "A completely new crystal-growth device has been developed that permits charting a course across the phase diagram to produce crystalline samples optimized for diffraction experiments. The utility of the device is demonstrated for the production of crystals for the traditional X-ray diffraction data-collection experiment, of microcrystals optimal for data-collection experiments at a modern microbeam insertion-device synchrotron beamline and of nanocrystals required for data collection on an X-ray laser beamline.",

author = "Arne Meyer and Karsten Dierks and Dierk Hilterhaus and Thomas Klupsch and Peter M{\"u}hlig and Jens Kleesiek and Robert Sch{\"o}pflin and Howard Einspahr and Rolf Hilgenfeld and Christian Betzel",

year = "2012",

month = aug,

day = "1",

doi = "10.1107/S1744309112024074",

language = "English",

volume = "68",

pages = "994--998",

journal = "Acta Crystallographica Section F: Structural Biology and Crystallization Communications",

number = "8",

}

TY - JOUR

T1 - Single-drop optimization of protein crystallization

AU - Meyer, Arne

AU - Dierks, Karsten

AU - Hilterhaus, Dierk

AU - Klupsch, Thomas

AU - Mühlig, Peter

AU - Kleesiek, Jens

AU - Schöpflin, Robert

AU - Einspahr, Howard

AU - Hilgenfeld, Rolf

AU - Betzel, Christian

PY - 2012/8/1

Y1 - 2012/8/1

N2 - A completely new crystal-growth device has been developed that permits charting a course across the phase diagram to produce crystalline samples optimized for diffraction experiments. The utility of the device is demonstrated for the production of crystals for the traditional X-ray diffraction data-collection experiment, of microcrystals optimal for data-collection experiments at a modern microbeam insertion-device synchrotron beamline and of nanocrystals required for data collection on an X-ray laser beamline.

AB - A completely new crystal-growth device has been developed that permits charting a course across the phase diagram to produce crystalline samples optimized for diffraction experiments. The utility of the device is demonstrated for the production of crystals for the traditional X-ray diffraction data-collection experiment, of microcrystals optimal for data-collection experiments at a modern microbeam insertion-device synchrotron beamline and of nanocrystals required for data collection on an X-ray laser beamline.

UR - https://www.scopus.com/pages/publications/84864871233

U2 - 10.1107/S1744309112024074

DO - 10.1107/S1744309112024074

M3 - Journal articles

C2 - 22869140

AN - SCOPUS:84864871233

VL - 68

SP - 994

EP - 998

JO - Acta Crystallographica Section F: Structural Biology and Crystallization Communications

JF - Acta Crystallographica Section F: Structural Biology and Crystallization Communications

IS - 8

ER -

Single-drop optimization of protein crystallization

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this