Single-drop optimization of protein crystallization

Arne Meyer, Karsten Dierks, Dierk Hilterhaus, Thomas Klupsch, Peter Mühlig, Jens Kleesiek, Robert Schöpflin, Howard Einspahr, Rolf Hilgenfeld, Christian Betzel*

*Corresponding author for this work
10 Citations (Scopus)


A completely new crystal-growth device has been developed that permits charting a course across the phase diagram to produce crystalline samples optimized for diffraction experiments. The utility of the device is demonstrated for the production of crystals for the traditional X-ray diffraction data-collection experiment, of microcrystals optimal for data-collection experiments at a modern microbeam insertion-device synchrotron beamline and of nanocrystals required for data collection on an X-ray laser beamline.

Original languageEnglish
JournalActa Crystallographica Section F: Structural Biology and Crystallization Communications
Issue number8
Pages (from-to)994-998
Number of pages5
Publication statusPublished - 01.08.2012


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